Registration Dossier
Registration Dossier
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EC number: 810-268-8 | CAS number: 1438383-92-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-acetyl-8,9,10,11-tetrahydro-5H-6-oxatetraphen-8-one
- EC Number:
- 810-268-8
- Cas Number:
- 1438383-92-6
- Molecular formula:
- C19H16O3
- IUPAC Name:
- 3-acetyl-8,9,10,11-tetrahydro-5H-6-oxatetraphen-8-one
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test system
- Duration of treatment / exposure:
- 3 minutes and 60 minutes at room temperature
- Number of animals:
- none
Results and discussion
Any other information on results incl. tables
Mean cell viability in the tissues treated with the test item was 109.156% at 3 minute exposure period and 94.292% at 60 minute exposure period. Significant reduction in cell viability was not observed at any of the exposure period in the treated tissues when compared with the concurrent negative control. Differences between the viability of treated tissues was less than 10% i.e. % CV.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the specified experimental conditions, the test ite is concluded to be non-corrosive in in vitro skin corrosion test using reconstructed human epidermis (RHE) tissues.
- Executive summary:
The test item has obligatory labelling requirement for skin irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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