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EC number: 915-334-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given. There were omly few details on materials and methods reported in the study, the purity of the test substance was not specified.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted Oct 2012
- Deviations:
- yes
- Remarks:
- few details on materials and methods, analytical purity not reported
- GLP compliance:
- no
Test material
- Reference substance name:
- octadecyl heptanoate; octadecyl octanoate
- EC Number:
- 915-334-0
- Molecular formula:
- C25H50O2 C26H52O2
- IUPAC Name:
- octadecyl heptanoate; octadecyl octanoate
- Details on test material:
- - Name of test material (as cited in study report): only trade name given
- Physical state: white, waxy substance
- Analytical purity: no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Bantin and Kingman Animals Ltd.
- Weight at study initiation: 2.5 - 3.5 kg (males and females)
- Diet: standard rabbit diet, ad libitum
- Water: not specified, ad libitum
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the untreated eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL - Duration of treatment / exposure:
- Single application without washing
- Observation period (in vivo):
- 7 days
Reading time points: 1, 24, 48 and 72 h, and 7 days - Number of animals or in vitro replicates:
- 3 males and 3 females
- Details on study design:
- SCORING SYSTEM: FDA scoring system, identical to Draize scoring system, except a score of 0.5 is possible
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: reversibility: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1 and #5
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 1.33
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 1.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #3, #4 and #6
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 d
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 d
- Irritant / corrosive response data:
- 4/6 rabbits had slight chemosis (score 1) and 2/6 had moderate chemosis (score 2) at the 1-hour reading time point. Slight chemosis persisted in 6/6 animals until the 72-hour reading time point, then cleared completely by 7 days after application. Slight to moderate conjunctivae was observed in 6/6 rabbits from the 1-hour reading time point. The conjunctivae persisted in all animals until the 72-hour reading time point, although the severity was reduced to score 1 in all animals. 7 days after instillation, 2/6 rabbits had slight conjunctivae, while the other 4/6 had no remaining eye effects. No effects were seen on the cornea and iris.
Any other information on results incl. tables
Table 1. Individual eye irritation scores
Rabbit #
|
Time
|
conjunctivae
|
iris
|
cornea
|
|
redness |
swelling |
||||
1
|
1 h |
2 |
1 |
0 |
0 |
24 h |
2 |
1 |
0 |
0 |
|
48 h |
1 |
0.5* |
0 |
0 |
|
72 h 7 d |
1 0.5* |
0.5* 0 |
0 0 |
0 0 |
|
Average* |
1.33 |
1.0 |
0.0 |
0.0 |
|
2
|
1 h |
2 |
1 |
0 |
0 |
24 h |
2 |
1 |
0 |
0 |
|
48 h |
2 |
1 |
0 |
0 |
|
72 h 7 d |
1 0 |
1 0 |
0 0 |
0 0 |
|
Average* |
1.67 |
1.0 |
0.0 |
0.0 |
|
3
|
1 h |
1 |
2 |
0 |
0 |
24 h |
1 |
1 |
0 |
0 |
|
48 h |
0.5* |
0.5* |
0 |
0 |
|
72 h 7 d |
0.5* 0 |
0.5* 0 |
0 0 |
0 0 |
|
Average* |
1.0 |
1.0 |
0.0 |
0.0 |
|
4
|
1 h |
1 |
1 |
0 |
0 |
24 h |
1 |
1 |
0 |
0 |
|
48 h |
1 |
1 |
0 |
0 |
|
72 h 7 d |
0.5* 0 |
0.5* 0 |
0 0 |
0 0 |
|
Average* |
1.0 |
1.0 |
0.0 |
0.0 |
|
5
|
1 h |
2 |
1 |
0 |
0 |
24 h |
2 |
1 |
0 |
0 |
|
48 h |
1 |
0.5* |
0 |
0 |
|
72 h 7 d |
1 0.5* |
0.5* 0 |
0 0 |
0 0 |
|
Average* |
1.33 |
1.0 |
0.0 |
0.0 |
|
6
|
1 h |
1 |
2 |
0 |
0 |
24 h |
1 |
1 |
0 |
0 |
|
48 h |
0.5* |
1 |
0 |
0 |
|
72 h 7 d |
0.5* 0 |
0.5* 0 |
0 0 |
0 0 |
|
Average* |
1.0 |
1.0 |
0.0 |
0.0 |
*(24h+48h+72h)/3. The 0.5 scores were rounded up to 1 in order to follow the standard Draize scoring system.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
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