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Diss Factsheets
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EC number: 810-760-2 | CAS number: 149855-64-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
As indicated in a dermal absorption study, The esters of adjacent molecular size to Propylheptyl methacrylate, Ethylhexyl methacrylate and Dodecyl methacrylate are metabolised during penetration of the skin and are not expected to enter the circulation as the parent ester.
Gastro intestinal-, respiratory- and dermal absorption to a major extent are not expected due to physico chemical properties and in vitro dermal absorption studies, where methacrylate esters of molecular weight equal to or greater than butyl methacrylate were not detected in the receptor fluid and are not expected to enter the circulation as the parent ester.
Short description of key information on absorption rate:
Extrapolated from Ethylhexyl methacrylate and Dodecyl methacrylate data, Propylheptyll methacrylate appears to be absorbed through rat skin and epidermis to a low extent, 0.26 – 0.6 % in 24 hrs. It is fully metabolized to methacrylic acid during the passage (first-pass effect). As indicated by a PB-PK model used in this study, human skin is 14 times less permeable to methacrylate esters than rat skin.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - dermal (%):
- 0.6
Additional information
Experiments on the C8 ester Ethylhexyl methacrylate and the C12 ester Dodecyl methacrylate (Lauryl methacrylate) with rat skin and human epidermis demonstrate that the methacrylate esters of a molecular size adjacently to the C10 ester in principle can be dermally absorbed (0.26 – 0.6 % over 24 hrs).
As a tendency confirmed with experiments on esters up to a chain length of C8, absorption decreases with increasing ester chain length. Due to the slow diffusion and the metabolic competency of the skin, the ester undergoes complete hydrolysis to methacrylic acid and the long-chain alkyl alcohol. In the organism, the acid is further metabolised via the valine pathway of the citric acid cycle the alcohol may be further metabolised by the two standard metabolic pathways for fatty alcohols.
Absortion by inhalation can be almost excluded due to the low vapour pressure of the esters.
GI absorption is not a favoured route of absorption as well. Only few amounts of the esters may be absorbed by micellular solubilisation.Discussion on bioaccumulation potential result:
In principle, GI-, respiratory- and dermal absorption to a major extent is not expected due to physico chemical properties ( low water solubility:, molecular weight: 226 g/mol)
Metabolism of will start with hydrolysation resulting in methacrylic acid and propylheptanol. While the acid is further metabolised via the valine pathway of the citric acid cycle the alcohol may be further metabolised by the two standard metabolic pathways for fatty alcohols. Alkyl esters of methacrylic acid up to C8 (2-ethylhexyl methacrylate) showed rapid metabolism with half lives in rat blood of less than 30 min.
Experimental studies of the toxicokinetics of Ethylhexyl methacrylate and Dodecyl methacrylate are only available for dermal absorption. In this in vitro studies, the esters were not detected in the receptor fluid, only the metabolite methacrylic acid. Therefore, in analogy 2 -Propylheptyl methacrylate it is not expected to enter the circulation as the parent ester.
Discussion on absorption rate:
Extrapolated from Ethylhexyl methacrylate and Dodecyl methacrylate data, Isodecyl methacrylate appears to be absorbed through rat skin and epidermis to a low extent, 0.26 – 0.6 % in 24 hrs. It is fully metabolized to methacrylic acid during the passage (first-pass effect). As indicated by a PB-PK model used in this study, human skin is 14 times less permeable to methacrylate esters than rat skin.
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