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EC number: 942-520-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
An acute skin irritation study in rabbits has been conducted with the substance Guerbet alcohols, C24-26, branched and linear. The substance showed only slight irritant effects.
An eye irritation study in rabbits is available for Guerbet alcohols, C24-26, branched and linear shows no irritant effects of the substance.
No data on respiratory irritation are available for the substance or any other structurally related Guerbet alcohol.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The study was performed for the notification in other regions where authorities do not accept read-across nor in vitro data.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: laboratory breed, EUROLAP (F-35140 GOSNE)
- Age at study initiation: 9 or 12 weeks old
- Housing: single housing
- Diet (e.g. ad libitum): SAFE - 112, ad libitum
- Water (e.g. ad libitum): Drinking water ad libitum
- Acclimation period: minimum 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 to 23
- Humidity (%): 30 to 70
- Air changes (per hr): at least 10 per hour
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml per kg bw was applied undiluted - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1 hour, and then 24, 48 and 72 hours aftter patch removal
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm² of shaved skin of the dorsal and lateral parts of the trunk of the animals
- coverage: patch (25 mm x 25 mm) non woven swab of 4.layer (MEDISTOCK)
- Type of wrap if used: sugical adhesive tape (50 mm wide hypoallergienic micropore adhesive tape from 3M)
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 4 hours
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours after patch removal
- Score:
- ca. 1.33
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 or 14 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 after patch removal
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- A very slight to well defied erythema was noted on the treated area 24 hours after patch removal in all animals which was totally reversible between 7 and 14 days.
- Other effects:
- On the cutaneous structure, dryness of the skin was noted in one animal on day 3 and in a second animal on day 7. The skin recovered to a normal aspect on day 14.
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of this study, the substance Guerbet alcohols, C24-26, branched and cyclic is slightly irritating to the skin.
- Executive summary:
An acute dermal irritation study was conducted on 3 New Zealand rabbits accoidn to OEECD Test Guideline 404. 0.5 ml of the test substace Guerbet alcohols, C24 -26, branched and cyclic were applied to the undamaged skin of the animals under semioccusive conditions for 4 hours. A very slight to well defied erythema was noted on the treated area 24 hours after patch removal in all animals which was totally reversible between 7 and 14 days. Based on the results of this study, the substance Guerbet alcohols, C24-26, branched and cyclic is slightly irritating to the skin.
Reference
Table 1: Irritant/corrosive response data for each animal at each observation time point
Score at time point / Reversibility |
Erythema |
Edema |
Max. score: 4 |
Max. score: 2 |
|
1 h |
0/1/1 |
0/0/0 |
24 h |
1/2/1 |
0/0/0 |
48 h |
1/2/1 |
0/0/0 |
72 h |
1/2/1 |
0/0/0 |
Day 7 |
0/1/0 |
0/0/0 |
Day 14 |
0/0/0 |
0/0/0 |
Average 24h, 48h, 72h | 1.33 | 0 |
Reversibility*) |
c | - |
*) Reversibility: c. = completely reversible;n.c.= not completely reversible; n. = not reversible
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The study was performed for the notification in other regions where authorities do not accept read-across nor in vitro data.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: laboratory breed, EUROLAP (F-35140 GOSNE)
- Age at study initiation: 9 or 12 weeks old
- Housing: single housing
- Diet (e.g. ad libitum): SAFE - 112, ad libitum
- Water (e.g. ad libitum): Drinking water ad libitum
- Acclimation period: minimum 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 to 23
- Humidity (%): 30 to 70
- Air changes (per hr): at least 10 per hour
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 ml - Duration of treatment / exposure:
- single administration, in each animal the test article was introduced into the conjunctival sac of one eye after gently pulling the lower lid away from the eyeball, afterwards the eyelid was closed for 1 second. The other eye remeined untreated serving as control. Unlimited exposure (not rinsed).
- Observation period (in vivo):
- 1 hour, 24, 48 and 72 hours following treatment.
- Number of animals or in vitro replicates:
- 3 male
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: no - Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.22
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- ca. 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- ca. 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Other effects:
- none
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the result of this study, the substance Guerbet alcohols, C24-26, branched and cyclic is not irritating to the eyes.
- Executive summary:
An acute eye irritation study was performed in three New Zealand rabboitsa according to OECD tEst Guideline 405. The test item Guerbet alcohols, C24 -26, branched and cyclis was instilled undiluted into the eyes of the rabbits at the dose of 0.1 ml. The ocular reactions observed during the study have been slightl and totally reversible, Based on the result of this study, the substance Guerbet alcohols, C24-26, branched and cyclic is not irritating to the eyes.
Reference
Table 1: Irritant/corrosive response data at each observation time
Score at time point / Reversibility |
Cornea |
Iris |
Conjunctivae Redness |
Conjunctiva Chemosis |
|
1 h |
0 (3) |
0 (3) |
1 (3) |
1 (2) 0 (1) |
|
24 h |
0 (3) |
0 (3) |
1 (2) 0 (1) |
0 (3) |
|
48 h | 0 (3) | 0 (3) | 0 (3) | 0 (3) | |
72 h | 0 (3) | 0 (3) | 0 (3) | 0 (3) | |
Average 24, 48, 72 h | 0 | 0 | 0.22 | 0 | |
Reversibility * | n.a. | n. a. | c. | c. |
* Reversibility: c. = completely reversible; n.c. = not completely reversible; n. = not reversible, n.a.= not applicable
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
The available data are conclusive but not sufficient for classification of Guerbet alcohols, C24-26, branched and linear with regard to irritation/corrosion.
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