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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Does not meet criteria of today standard methods. No official test guideline has been developed for this test; the reliability of the result can therefore not be judged.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1960
Report date:
1960

Materials and methods

Type of sensitisation studied:
skin
Study type:
study with volunteers
Test guideline
Qualifier:
according to guideline
Guideline:
other: method of Shelanski and Shelanski (Proceedings of the Toilet Goods Association, Number 10, May 1953).
Principles of method if other than guideline:
50 volunteeers were treated repeatedly with insult patches containing a 5% suspension of the test substance in corn oil.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Etocrilene
EC Number:
226-029-0
EC Name:
Etocrilene
Cas Number:
5232-99-5
Molecular formula:
C18H15NO2
IUPAC Name:
ethyl 2-cyano-3,3-diphenylprop-2-enoate

Method

Type of population:
not specified
Ethical approval:
not specified
Subjects:
- Number of subjects exposed: 50
Controls:
no data
Route of administration:
dermal
Details on study design:
TYPE OF TEST(S) USED: patch test (epicutaneous test)

ADMINISTRATION
- Vehicle / solvent: corn oil
- Concentrations: 5%

Results and discussion

Results of examinations:
None of the fifty subjects reacted to any of the 15 applications or to the challenge application.

Applicant's summary and conclusion

Conclusions:
From the results obtained, in this study on the fifty subjects used, the test article, tested as a 5% w/v solution in corn oil, was found to be neither a primary irritant nor a fatiguing agent to any of the subjects tested. This material did not produce sensitization in any of the subjects tested.