Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-942-7 | CAS number: 89-81-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- The study was conducted in 1975.
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract only.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was administered orally to rats at a range of concentrations and the rats were observed for fourteen days.
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP.
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 6-isopropyl-3-methylcyclohex-2-enone
- EC Number:
- 201-942-7
- EC Name:
- 6-isopropyl-3-methylcyclohex-2-enone
- Cas Number:
- 89-81-6
- Molecular formula:
- C10H16O
- IUPAC Name:
- 6-isopropyl-3-methylcyclohex-2-enone
- Test material form:
- not specified
- Details on test material:
- Name: Piperitone
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- The test substance was administered orally to rats at a range of concentrations and the rats were observed for fourteen days.
- Doses:
- 1.31, 2.56, 5.0 and 9.75 g/kg.
- No. of animals per sex per dose:
- 10 animals per dose, sex not specified.
- Control animals:
- no
- Details on study design:
- The test substance was administered orally to rats at a range of concentrations and the rats were observed for fourteen days.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 550 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 450 - 4 650
- Mortality:
- Mortality occurred at 2.56, 5.0 and 9.75 g/kg.
- Clinical signs:
- other: At 1.31 g / kg and 2.56 g / kg slight lethargy was observed. At 5.0 g/kg lethargy and piloerection were observed. At 9.75 g/kg coma was observed.
Any other information on results incl. tables
Summary of mortality
Dose g/kg |
Death / No. of animals |
Observation day |
|||||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
||
1.31 |
0 / 10 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2.56 |
2 / 10 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
5.0 |
8 / 10 |
7 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
9.75 |
10 / 10 |
9 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 was 3.55 g/kg with 95 % confidence limits of 2.45 – 4.65 g/kg.
- Executive summary:
The acute oral toxicity of the test substance was assessed. The acute oral LD50 was 3.55 g/kg with 95 % confidence limits of 2.45 – 4.65 g/kg. Therefore no classification is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
