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Diss Factsheets
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EC number: 205-619-1 | CAS number: 144-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
The potential for 2,2,4-trimethyl-1,3-pentanediol to cause dermal sensitization was evaluated based on one key and three supporting studies in which the test material in various solvents was applied epicutaneously to the clipped backs of guinea pigs. The test material was periodically reapplied to the guinea pig backs for two weeks and average irritation scores for treated and control animals were compared 24 and 48 hours after the last application. The test method used in these studies is not one of the recognized and officially accepted animal test methods outlined in current regulatory guidelines. However, when the tests are evaluated together, they provide evidence that the test material has a low potential to cause dermal sensitization. In the key study which used a 1% mixture of the test material in a 1:1:3 acetone:dioxane:guinea pig fat vehicle, ten animals were repeatedly treated with the test mixture while five animals each received the vehicle or positive control. Two of the ten treated animals showed a weak response. The average final irritation score in the test group was 1.6 48 hours after the final application compared to average scores of 1.1 and 3.2 for the vehicle and positive control groups, respectively. In the first supporting study, groups of five guinea pigs were repeatedly exposed to either 0.1M test material in a 1:1:3 acetone:dioxane:corn oil vehicle, vehicle alone, or the positive control substance phenylhydrazine. Under the conditions of the study, 2,2,4-trimethyl-1,3-pentanediol did not cause a significant increase in average irritation score when compared to the controls. In the second supporting study, four animals were treated with a 40% solution of the test material in ethanol while five animals were treated with solvent alone and three animals were treated with phenylhydrazine. 2,2,4-Trimethyl-1,3-pentanediol did not produce a positive response based on an average final irritation score of 1.1 compared to 1.0 for the vehicle control. In the third supporting study, guinea pigs were repeatedly treated with 10% of a stock solution of 40% TMPD:40% ethanol:20% water in an acetone: dioxane:guinea pig fat vehicle. Average irritation scores for both the test group and the vehicle control were 1.0 48 hours after the last treatment. In all four studies, the vehicles and positive controls induced the appropriate responses.
Justification for classification or non-classification
2,2,4-Trimethyl-1,3-pentanediol is not currently classified for Skin Sensitization according to Annex I of Directive 67/548/EEC. Based on a weight-of-the-evidence assessment, 2,2,4-trimethyl-1,3-pentanediol is not classified for Skin Sensitization according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 and UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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