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EC number: 219-371-7 | CAS number: 2425-79-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- Guideline study without detailed documentation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- -reliability scoring based on 1987 guideline
- Deviations:
- yes
- Remarks:
- -Information on purity, source, and physico-chemical properties, acclimatization period not reported; observation period was 7 days; 3/sex/group; insufficient details provided on type of occlusion and exposed skin area; no individual data
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP requirements.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,4-bis(2,3-epoxypropoxy)butane
- EC Number:
- 219-371-7
- EC Name:
- 1,4-bis(2,3-epoxypropoxy)butane
- Cas Number:
- 2425-79-8
- Molecular formula:
- not applicable, UVCB
- IUPAC Name:
- N,N-dimethylacetamide
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): TK 10352.
- Analytical purity: Not reported.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif.: RAI/f
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Testing facility breeding unit.
- Age at study initiation: 7 to 8 weeks old.
- Weight at study initiation: 180 to 200 g.
- Fasting period before study: Not reported.
- Housing: Housed singly in Macrolon cages (Type 3).
- Diet (e.g. ad libitum): Rat food (NAFAG, Gossau SG), ad libitum.
- Water (e.g. ad libitum): Water, ad libitum.
- Acclimation period: Not reported.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±1.
- Humidity (%): Approximately 50.
- Air changes (per hr): Not reported.
- Photoperiod (hrs dark / hrs light): Not reported.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Rats' back.
- % coverage: Not reported.
- Type of wrap if used: Area was covered with aluminium foil, which was held around the trunk with ISO-ELAST plaster.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Skin was cleaned with warm water to remove all traces of the suspension.
- Time after start of exposure: 24 hours after start of exposure.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Not reported.
- Concentration (if solution): Not reported.
- Constant volume or concentration used: Not reported.
- For solids, paste formed: Not reported.
VEHICLE
- Amount(s) applied (volume or weight with unit): Not reported.
- Concentration (if solution): Not reported.
- Lot/batch no. (if required): Not reported.
- Purity: Not reported. - Duration of exposure:
- 24 hours.
- Doses:
- 2150 mg/kg body weight.
- No. of animals per sex per dose:
- 3 per sex.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days.
- Frequency of observations and weighing: Mortality was observed within 1, 24, and 48 hours and within 7 days.
- Necropsy of survivors performed: Yes. - Statistics:
- Not reported.
Results and discussion
- Preliminary study:
- Not applicable.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 150 mg/kg bw
- Remarks on result:
- other: None
- Mortality:
- No mortalities were reported.
- Clinical signs:
- other: No symptoms and no local skin irritation were observed.
- Gross pathology:
- The rats were killed and autopsied after an observation period of 7 days. No substance related gross organ changes were seen in any animals.
- Other findings:
- No other findings reported.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Information Criteria used for interpretation of results: CLP (EC 1272/2008)
- Conclusions:
- The acute dermal LD50 of the test substance in rats of both sexes observed over a period of 7 days is >2150 mg/kg body weight. No mortality was observed.
- Executive summary:
The compound was tested on 6 Tif,: RAI/f rats (3 males/3 females), bred under SPF conditions. They were 7 to 8 weeks old and weighed 180 to 200 g.
Approximately 6 hours before treatment the rats' backs were shaved with an electric razor. The suspension containing 2150 mg/kg bw (for technical reasons no higher doses were possible) was evenly dispersed on the skin with a Record syringe and covered with aluminium foil, which was held around the trunk with IS0-ELAST plaster. After 24 hours the plaster and the aluminium foil were peeled off carefully and the skin was cleaned with warm water to remove all traces of the suspension.
During treatment and for the 7 day observation period the rats were housed singly in Macrolon cages (Type 3) in a room kept at a constant temperature of 22 ±1 °C and a relative humidity of approximately 50%. They were given water and food ad libitum.
None of the animals died during the entire treatment and observation period. No symptoms and no local skin irritation were observed.
The rats were killed and autopsied after an observation period of 7 days; no substance related gross organ changes were seen.
In conclusion the acute dermal LD50 of the test substance in rats of both sexes observed over a period of 7 days is >2150 mg/kg body weight.
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