Registration Dossier
Registration Dossier
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EC number: 226-109-5 | CAS number: 5281-04-9
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Common carp
- Source: obtained from a commercial fish farm in Japan
- Length at study initiation: 10 cm
- Weight at study initiation: 30 g
ACCLIMATION
- Acclimation conditions: flow through at 25 ± 2 °C
- Type and amount of food: obtained from a commercial fish farm in Japan at a rate of 2% of the total body weight
- Feeding frequency: daily, no feeding at the day of sampling - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 6 wk
- Test temperature:
- 25 ± 2 °C
- Details on test conditions:
- TEST SYSTEM
- Volume = 100 L
- Renewal rate of test solution: 200 - 800 mL/min
- No. of vessels per concentration: 15 - 20
- No. of vessels per control / vehicle control: 15 - 20
TEST MEDIUM / WATER PARAMETERS
- Holding medium different from test medium: no
- Intervals of water quality measurement: twice a week - Nominal and measured concentrations:
- 0.3 mg/L and 0.03 mg/L
- Key result
- Conc. / dose:
- 0.03 mg/L
- Temp.:
- >= 23 - <= 27 °C
- Type:
- BCF
- Value:
- < 6.9 L/kg
- Time of plateau:
- 42 d
- Conc. / dose:
- 0.3 mg/L
- Temp.:
- >= 23 - <= 27 °C
- Type:
- BCF
- Value:
- >= 0.7 - <= 1.8 L/kg
- Time of plateau:
- 42 d
Reference
Description of key information
Does not significantly accumulate in organisms
Key value for chemical safety assessment
Additional information
Bioaccumulation of the substance is not expected due to the low log Pow of 0.65.
The is supported by a guideline study on the bioaccumulation of the substance. Fish (Cyprinus carpio) were exposed to test substance concentrations of 0.3 mg/L and 0.03 mg/L respectively. The test was terminated after 6 weeks of exposure. At a substance concentration of 0.3 mg/L a BCF of 0.7 - 1.8 was determined. At a concentration of 0.03 mg/L a BCF < 6.9 was detected (JETOC, 1992).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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