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EC number: 203-572-1 | CAS number: 108-32-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity- oral: An oral LD50 of > 5000 mg/kg bw was determined in male/female Sprague-Dawley rats 14 days after treatment with propylene carbonate according to OECD Guideline 401. As acute oral LD50 rat is approximately 32319 mg/kg propylene carbonate may be considered as practically non-toxic after a single ingestion.
Acute toxicity- inhalation: No reliable studies were available for the inhalation route.
Acute toxicity- dermal: A dermal LD50 of > 2000 mg/kg bw was determined male/female New Zealand White rabbits 14 days after treatment with propylene carbonate according to OECD Guideline 402.
Acute toxicity- other routes: The LD50 values for single subcutaneous exposure were 15.8 mL/kg bw in mice and 11.1 mL/kg bw in rats after 72 hours of observation.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute toxicity: oral
Pharmakon Research International, Inc. (1985) investigated the acute oral toxicity via gavage of 5000 mg/kg bw propylene carbonate in 10 Sprague-Dawley male/female rats. After 14 days of observation, no mortality has been observed and an LD50 of > 5000 mg/kg bw was reported. This study is designated as key study. In addition, BASF (1960) observed an acute oral LD50 of 32319 mg/kg bw in Schmitt-Fischer and Hanover male/female rats 7 days after treatment.
Acute toxicity: inhalation
No reliable studies were available for the inhalation route. A waiver statement was added and justified as following: next to the oral route of exposure, for substances other than gases, the information mentioned under 8.5.2 to 8.5.3 shall be provided for at least one other route (REACH Regulation, column 2 adaptation of Annex VIII). For propylene carbonate, a key study is available for the dermal route of exposure. Therefore, an acute inhalation toxicity study should not be performed.
Acute toxicity: dermal
Mallory (1985) investigated acute dermal toxicity of propylene carbonate in 10 New Zealand White male/female rabbits after 24 hours of exposure. After 14 days of observation, an LD50 value of > 2000 mg/kg bw was reported. This study is designated as key study. In addition, Mallory (1986) observed an LD50 of > 3000 mg/kg bw in the same rabbit species under similar conditions.
Acute toxicity: other routes
Kuramoto (1972) investigated acute toxicity via the subcutaneous route of exposure (1 injection) in male mice and rats. The LD50 values after 72 hours of observation were 15.8 mL/kg bw in mice and 11.1 mL/kg bw in rats.
Justification for classification or non-classification
Based on the available data, propylene carbonate should not be classified for acute oral and acute dermal toxicity according to the criteria as specified in the CLP Regulation (EC) No 1272/2008. No data are available on the acute inhalation toxicity to decide on the classification for this route of exposure.
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