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EC number: 215-170-3 | CAS number: 1309-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30-04-2010 to 17-05-2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 13320:2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- other: Counted and volumetric distribiution
- Specific details on test material used for the study:
- - Name: Magnesium hydroxide
- Batch no. 20BR0026
- CAS No.: 1309-42-8
- Purity: 99.9 %
- Expiry date: 31 January 2012
- Storage Room Temp. in the dark - Mass median aerodynamic diameter:
- 21.601 µm
- Percentile:
- D10
- Mean:
- 2.013 µm
- St. dev.:
- 0.14
- Key result
- Percentile:
- D50
- Mean:
- 13.915 µm
- St. dev.:
- 0.63
- Remarks on result:
- other: Median
- Percentile:
- D90
- Mean:
- 154.107 µm
- St. dev.:
- 32.43
- No.:
- #1
- Size:
- < 2.013 µm
- Distribution:
- 10 %
- No.:
- #2
- Size:
- < 13.915 µm
- Distribution:
- 50 %
- No.:
- #3
- Size:
- < 154.107 µm
- Distribution:
- 90 %
- Conclusions:
- The MMAD (Mass Median Aerodynamic Diameter) was determined to be 21.601 µm. 34.19 % by volume of sample was seen to be < 10.00 µm.
- Executive summary:
In a GLP study and according to OECD 110, CIPAC MT 187 and ISO 13320:2009 the particle size was analysed via laser diffraction. The MMAD (50% percentile) was 21.601 µm.
Average (µm)
Volume weighted mean
43.893
Median (d.50)
13.915
Mode (µm)
14.311
MMAD (mass median aerodynamic diameter)
21.601
10 % of material is <
2.013
50 % of material is <
13.915
90 % of material is <
154.107
Reference
Optical microscope analysis:
Standard visual observation: Sample observed to be medium size, white powder with clusters.
Observation at 100 x magnification: The particles appeared to be irregularly shaped, round edged particles. The smallest individual particle size was approximately 3 µm and the largest individual particle size was approximately 8 µm. This analysis ignores clusters and agglomerates.
Observation at 400 x magnification: The sample was observed to be made up of agglomerated particles.
Laser diffraction particle size analysis:
The method development phase of the analysis indicated that the most appropriate test and material parameters to obtain the optimum measurement were:
Dispersant: Air
Dispersion pressure: 0.5 barg
Refractive index (sample): 1.559 n
Absorption: 0 AU
Analysis model: General purpose (normal)
Using the identified parameters, the particle size was analysed over the range 0.02 µm to 2000 µm. The results of the formal analysis are presented in Table 1, and the standard deviation results are recorded in Table 2. In addition, a graph of volume (%) versus particle diameter (µm), and full particle size distribution, is provided which is an average of the 5 runs.
Table 1. Full Test Results
|
Run 1 |
Run 2 |
Run 3 |
Run 4 |
Run 5 |
Average* |
Volume weighted mean |
48.763 |
53.790 |
39.690 |
39.096 |
38.125 |
43.893 |
Median (d.50) |
14.982 |
14.349 |
13.574 |
13.415 |
13.350 |
13.915 |
Mode (µm) |
15.169 |
14.261 |
14.099 |
14.066 |
14.034 |
14.311 |
MMAD |
23.258 |
22.275 |
21.072 |
20.826 |
20.725 |
21.601 |
10 % of material is < |
2.266 |
2.113 |
1.944 |
1.921 |
1.893 |
2.013 |
50 % of material is < |
14.982 |
14.349 |
13.574 |
13.415 |
13.350 |
13.915 |
90 % of material is < |
176.935 |
211.778 |
135.845 |
134.752 |
126.672 |
154.107 |
* Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.
34.19 % by volume of sample was seen to be < 10.0 µm.
Table 2. Standard Deviation Results
Run No. |
1 |
2 |
3 |
4 |
5 |
STDVP |
% STDV |
d10 |
2.266 |
2.113 |
1.944 |
1.921 |
1.893 |
0.14 |
7.00 |
d50 |
14.982 |
14.349 |
13.574 |
13.415 |
13.350 |
0.63 |
4.55 |
d90 |
176.935 |
211.778 |
135.845 |
134.752 |
126.672 |
32.43 |
20.63 |
d15.78 |
5.202 |
4.825 |
4.103 |
4.005 |
3.827 |
0.53 |
12.03 |
GSD (geometric standard deviation) |
2.880 |
2.974 |
3.308 |
3.350 |
3.488 |
0.23 |
7.27 |
MMAD |
23.258 |
22.275 |
21.072 |
20.826 |
20.725 |
0.98 |
4.55 |
Coefficient of variation is outside the normal acceptable limits (d50 should be less than 3 %; d10 and d90 should be less than 5 %). This is due to agglomerations in the sample that could not be separated. Earlier attempts to separate these agglomerations failed resulting in poor reproducibility and uncertainty as to the accuracy of the results. Whilst the results for the material tested in the "as received" condition are still variable, they do reflect the particle size distribution of the sample in the "as received" condition.
Description of key information
The MMAD (mass median aerodynamic diameter) was determined to be 21.601 µm.
Additional information
The MMAD (mass median aerodynamic diameter) was determined to be 21.601 µm. 34.19 % by volume of sample was seen to be < 10.00 µm.
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