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EC number: 406-080-7 | CAS number: 83016-70-0 JEFFCAT ZF-10; TEXACAT ZF-10
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983-10-03 to 1983-10-31
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- Although signs of toxicity and effects in organs for individual animals dosed at 1000 mg/kg were missing from the report, the UK c.a. considers that overall an adequate description of the toxic effects was given. Experimental test were run under GLP conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 5601-22-20, Order # J-174
- Physical state: Light yellow liquid
- Lot/bach No.: Order # J-174
- Stability under test conditions: There was no apparent change in the physical state of the test article during administration
- Other: base factor: Specific gravity = 0.952 g/ml; 1 quart supplied on September 26, 1983; the purity of the test article is the responsibility of the sponsor
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Blue Spruce Farms, Altamont, New York
- Weight at study initiation: 180-360 g (weight variation in animals or between groups did not exceed +/- 20%)
- Fasting period before study: 18 hours
- Housing: Rats housed in groups, according to sex, or individually in stainless steel 1/2" wire mesh cages.
- Diet (e.g. ad libitum): Wayne Lab BloxR, ad libitum
- Water (e.g. ad libitum): Fresh tap water, fit for human consumption, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: None (Liquid substance used undiluted)
- Doses:
- 800, 1000, 1600, and 2000 mg/kg
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The rats were observed at approximately 1, 2, 4 and 24 hours after dosing and twice daily for 14 days for pharmacotoxic, CNS effects and mortality. On days 7 and 14, body weights were recorded.
- Necropsy of survivors performed: yes - Statistics:
- According to the method of Litchfield and Wilcoxon (1949) JPET 96:99-114
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 364 mg/kg bw
- 95% CL:
- 1 110 - 1 675
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 693 mg/kg bw
- 95% CL:
- 1 433 - 1 999
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 007 mg/kg bw
- 95% CL:
- 830 - 1 222
- Mortality:
- Mortality by Sex and Dose:
Male: 800 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1600 mg/kg bw; Number of animals: 5; Number of deaths: 2
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 800 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 1600 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 4
One out of ten died at the 800 mg/kg level, two out of ten died at the 1000 mg/kg level, seven out of ten died at 1600 mg/kg and eight out of ten died at 2000 mg/kg. - Clinical signs:
- other: Signs of toxicity related to dose levels: At 1600 mg/kg and 2000 mg/kg, all deaths occurred within 24 hours of dosing apart from one top dose female which died between 72 and 96 hours post exposure. At these doses, toxic signs were primarily decreased act
- Gross pathology:
- Effects on organs:
Necropsy of decedents dosed at 1600 and 2000 mg/kg generally showed distended stomachs and intestines with stomach haemorrhages. Discoloured or haemorrhagic intestines were noted in 2/7 and 1/8 decedents at 1600 and 2000 mg/kg respectively and two top dose decedents showed darkened adrenals. Effects in organs specifically for the 1000 mg/kg dose group were missing from the report. No macroscopic effects on organs were observed in surviving animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The calculated oral LD50 for male and female rats was determined to be 1364 mg/kg (1110-1675 mg/kg). The calculated oral LD50 for male rats was determined to be 1693 mg/kg (1433-1999 mg/kg). The calculated oral LD50 for female rats was determined to be 1007 mg/kg (830-1222 mg/kg). The substance is considered to be classified as acute oral toxicant category 4 according to the criteria laid down in the CLP Regulation (EC) 1272/2008.
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