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Reaction mass of 2-[[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]methyl]oxirane and 1,3-bis[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]propan-2-ol and 1-[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]-3-[4-[[4-[3-[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]-2-hydroxy-propoxy]-3,5-dimethyl-phenyl]methyl]-2,6-dimethyl-phenoxy]propan-2-ol
EC number: 941-357-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: HPLC method; representative of sorption behaviour of the test substance on soil
- Radiolabelling:
- no
- Test temperature:
- Column temperature was 25°C
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Agilent 1200 Series Liquid Chromatograph with Chemstation software
- Column: HyperClone CN (CPS) (25 cm x 4.6 mm internal diameter)
- Flow rate: 1.0 mL/Minute
- Injection volume: 10 μL
- Detection system: UV set at 210 nm
MOBILE PHASES
- Type: Mobile phase A (Methanol: water (55:45 v/v), Mobile phase B (Methanol).
DETERMINATION OF DEAD TIME
- Method: An internal standard (formamide) with no retention on the HPLC column was used to determine the dead time of the HPLC system.
REFERENCE SUBSTANCES
- Identity: Internal dead time standard (formamide), Acetanilide, Nitrobenzene, Naphthalene, 2-Methylnaphthalene, Anthracene and DDT with known LogKoc values.
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 10 μL (approximately 90 mg/L in mobile phase A).
- Quantity of reference substances: 10 μL at varying appropriate concentrations (3-200 mg/L).
REPETITIONS
- Number of determinations: Duplicate
EVALUATION
- Calculation of capacity factors k':
K = ((measured retention time of sample or reference)-(the retention time of the internal deadtime standard))/the retention time of the internal deadtime standard.
- Determination of the log Koc value: A calibration plot of Log10k vs Log10Koc was conducted for reference standards. The logarithm of the capacity factors for the test substance was then calculated and the log10Koc value determined by interpolation. - Type:
- log Koc
- Value:
- ca. 4.3
- Temp.:
- 25 °C
- Remarks on result:
- other: Major chromatographic component
- Type:
- log Koc
- Value:
- > 5.6
- Temp.:
- 25 °C
- Remarks on result:
- other: Significant components noted after retention time of highest available standard
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: Various (3.551 to 24.292 minutes)
- Details of fitted regression line (log k' vs. log Koc): Linear regression (based on mean of standard runs A and B): log10Koc = 2.88 log10k + 3.28
- Average retention data for test substance: The duplicate retention time values were 9.572 and 9.573 minutes. - Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance was determined to have a log10Koc value of 4.3 (equivalent Koc = 19000). The determined value was for the major chromatographic component. Other significant components were noted after the retention time of the highest available reference standard, DDT, indicating log10Koc values in excess of 5.6 for these.
Reference
Description of key information
A study is available assessing the adsorption coefficient of the test substance by the HPLC method according to the OECD guideline 121.
Key value for chemical safety assessment
- Koc at 20 °C:
- 19 000
Additional information
The major chromatographic component of the test substance provided a LogKoc value of 4.3 (Koc of 19,000). Other significant components were noted to have LogKoc values > 5.6. All components showed high potential for adsorption to soil (low mobility) in this screening test; the Koc value for the major component has been used in the CSA as representative for registerable substance.
Other adsorption coefficient indicated as dimensionless:
- other: Log Koc (other significant components) ,5.6 at the temperature
25.0°C
- other: Koc (other significant components) ,398107.0 at the temperature
25.0°C
Further information on adsorption/desorption would not be gained from
performance of additional testing as indicated in the results of the
study required under Annex VIII.
[LogKoc: 4.3]
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