Registration Dossier
Registration Dossier
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EC number: 931-534-0 | CAS number: 68439-57-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from Handbook or data collection. Sufficient for assessment.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- review article without detailed experimental data, occlusive application for 24 hours, only 2 non-abraded animals per dose
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sulfonic acids, C14-16 (even numbered)-alkane hydroxy and C14-16 (even numbered)-alkene, sodium salts
- EC Number:
- 931-534-0
- Cas Number:
- 68439-57-6
- Molecular formula:
- C(4+2n)H(9+4n)SO4Na C(4+2n)H(7+4n)SO4Na n = 5-6
- IUPAC Name:
- Sulfonic acids, C14-16 (even numbered)-alkane hydroxy and C14-16 (even numbered)-alkene, sodium salts
- Reference substance name:
- Sulfonic acids, C14-16 (even numbered)-alkane hydroxy and C14-16 (even numbered)-alkene, sodium salts
- IUPAC Name:
- Sulfonic acids, C14-16 (even numbered)-alkane hydroxy and C14-16 (even numbered)-alkene, sodium salts
- Test material form:
- other: aqueous formulation
- Details on test material:
- - Name of test material (as cited in study report): C14-16 Alpha olefin sulfonate
- Physical state: liquid
- Analytical purity: not reported
- Composition of test material, percentage of components: 36.9 % C14-16 AOS
- Other: pH 7-8; Source: Ethyl Corp.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: clipped trunk, not further specified
- Type of wrap if used: plastic sleeves
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data, but substance was removed after 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): not reported
- Concentration (if solution): 36.9 %
- Constant volume or concentration used: yes, constant concentration - Duration of exposure:
- 24 hours
- Doses:
- 6 samples with unknown concentrations
- No. of animals per sex per dose:
- 4 rabbits (2 abraded, 2 non-abraded, sex not specified)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 6 300 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: ±1340, Sample 1
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 16 000
- Based on:
- act. ingr.
- Remarks on result:
- other: Sample 2
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 10 000 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: ±1780, Sample 3
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 8 000 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: ±2900, Sample 4
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 13 500 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: ±1420, Sample 5
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 9 500 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: ±1600, Sample 6
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
Any other information on results incl. tables
Average LD50 for the test item at 36.9% was > 6000 mg/kg bw active ingredient for dermal exposure of rabbits.
According to the criteria of the DSD and the CLP regulation the test substance does not have to be classified for acute dermal toxicity.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- EU Directive 67/548/EEC: not classified
Regulation (EC) No 1272/2008: not classified
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