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Diss Factsheets
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EC number: 202-804-9 | CAS number: 99-96-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Tests without pH neutralisation:
Any tests without pH neutralisation revealed effects at concentrations in treatments with pH values significantly below 6. EC50/ LC50 were in the same range for all tested organisms:
EC50 (48 h) Daphnia magna = 67 mg/L (Biermann, (2009a),
LC50 (96 h)/ (14 d) Oryzias latipes (not considered as chronic toxicity test)= 92.8 mg/L/ 66.5 mg/L (Toray, 1997a/b),
ErC50 (72 h) Algae = 92 mg/L (Biermann, 2009b)
The pH-values in these tests were outside the acceptable range for validity or recommendations in the guidelines. It can be expected that the effects are mainly due to the low pH, which leads to an unphysiological milieu. Therfore, the effect concentrations of tests without pH-adjustments will not be used as key values for hazard assessment.
In tests with pH-adjustments to neutral values:
Tests with pH adjustments exhibited no effects/ effects at much higher concentrations. Therfore, the effect concentrations of tests without pH-adjustments will not be used as key values for hazard assessment.
No effects were observed at 100 mg/L for fish (Oryzias latipes, 14 days and 96 h, Toray (1997a/b)) and Daphnia magna (21 days, Toray (1997c). EC50 (48 h) Daphnia magna = 1690 mg/L. No effects were observed at 1000 mg/L in a study with Daphnia magna (48 h). In a study with algae (72 h) ErC10/EC50 was ca. 249 mg/L/>1000 mg/L
(Biermann, 2009b). 100 mg/L can be used as a no observe effect concentration as a worst case for chemical safety assessment.p-HBA (pKa=4.57) is considered a week acid. It can be expected from the Henderson Hasselbalch equation that the non-ionised form of p-Hydroxybenzoic acid will be the dominating species at pH-values below the pka of ca. 4.57.
The ionised form of p-HBA which is available at pH > pKa (pHBA) of 4.57 is less toxic than the non-ionised form. Further, the log P of both forms are different, (non-ionised: log P = 0.878, ionised form: log P = - 1.57). The substance in the form with higher logP should be more bioavailable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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