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EC number: 268-626-9 | CAS number: 68131-73-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Short summary of test results
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Acute percutaneous absorption test
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- female
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 2 females
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: After treatment, the rabbits appeared listless and had slight tremors. However, both recovered, appeared healthy, and gained weight during the 2-week observation period.
- Interpretation of results:
- other: CLP/EU GHS criteria are not met, no classification required according to Regulations (EC) No 1272/2008
- Conclusions:
- The LD50 via the dermal route appeared to be in excess of 2000 mg/kg bw.
- Executive summary:
A sample of polyethylenepolyamine neutralized, reference 30339-23-485, was submitted to the Acute Toxicology Laboratory of Health & Environmental Sciences-Texas for evaluation of acute percutaneous absorption and eye irritation potential. The test material, a reaction product of E-100, EDC,5 EPI/DETAand NaOH,also known as PAPA+1 (neutralized), was submitted by Chlor-Nitrogen Research.
Acute percutaneous absorption and eye Irritation tests were conducted using female Zealand albino rabbits (Ray Nichols Rabbitry).
The acute percutaneous absorption potential is low; range-finding tests indicate the LD50 is>2000 mg/kg. Two female rabbits were treated with 2000 mg/kg of the test material in an acute percutaneous absorption test. After treatment, the rabbits appeared restless and had slight tremors. However, both recovered, appeared healthy and gained weight during the 2-week observation period.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Amines, polyethylenepoly-
- EC Number:
- 268-626-9
- EC Name:
- Amines, polyethylenepoly-
- Cas Number:
- 68131-73-7
- Molecular formula:
- Not applicable (i.e., complex UVCB substance)
- IUPAC Name:
- Amines, polyethylenepoly-
- Details on test material:
- Polyethylenepolyamine, neutralized
Reference number 30339-23-485
a reaction product of E-100, EDC, 5EPI/DETA, and NaOH, also known as PAPA+1 (neutralized)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- eyes were washed and unwashed
- Observation period (in vivo):
- 15 days
- Number of animals or in vitro replicates:
- no data
Results and discussion
In vivo
- Irritant / corrosive response data:
- Instillation of the test material into the eyes of a rabbit resulted in severe pain, moderate conjunctival irritation, and moderate, transient clouding of the cornea. No irritationwasobserved in either the washed or unwashed eye 15 days post-instillation.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Instillation of the test material into the eyes of a rabbit resulted in severe pain, moderate conjunctival irritation, and moderate, transient clouding of the cornea.
- Executive summary:
A sample of polyethylenepolyamine neutralized, reference 30339-23-485, was submitted to the Acute Toxicology Laboratory of Health & Environmental Sciences-Texas for evaluation of acute percutaneous absorption and eye irritation potential. The test material, a reaction product of E-100, EDC,5 EPI/DETAand NaOH,also known as PAPA+1 (neutralized), was submitted by Chlor-Nitrogen Research.
Acute percutaneous absorption and eye Irritation tests were conducted using female Zealand albino rabbits (Ray Nichols Rabbitry).
Instillation of the test material into the eyes of a rabbit resulted in severe pain, moderate conjunctival irritation, and moderate, transient clouding of the cornea. No irritationwasobserved in either the washed or unwashed eye 15 days post-instillation. Chemical workers goggles should be worn whenever the likelihood of eye contact exists. If contact should occur, flush eyes with, plenty of flowing water.
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