Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 305 (Bioaccumulation in Fish: Aqueous and Dietary Exposure) -III: Dietary Exposure Bioaccumulation Fish Test
Deviations:
no
GLP compliance:
yes
Radiolabelling:
no
Vehicle:
no
Test organisms (species):
other: Rainbow trout, fish
Route of exposure:
feed
Justification for method:
dietary exposure method used for following reason: solubility of test substance analytical not to detect (LQ0 ~ 5ng/L)
Test type:
flow-through
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
14 d
Total depuration duration:
14 d
Reference substance (positive control):
not required
Lipid content:
4.28 %
Time point:
start of exposure
Lipid content:
4.79 %
Time point:
end of exposure
Lipid content:
6.76 %
Time point:
other: end of DEPURATION PHASE
Key result
Conc. / dose:
208 µg/g food
Temp.:
15 °C
pH:
6.8
Type:
BMF
Value:
0.003 dimensionless
Basis:
whole body w.w.
Calculation basis:
kinetic
Remarks on result:
not determinable because of methodological limitations
Remarks:
steady state not reached
Key result
Conc. / dose:
208 µg/g food
Temp.:
15 °C
pH:
6.8
Type:
BMF
Value:
0.006 dimensionless
Basis:
normalised lipid fraction
Calculation basis:
kinetic, corrected for growth
Remarks on result:
not determinable because of methodological limitations
Remarks:
steady state not reached
Key result
Elimination:
yes
Parameter:
DT90
Depuration time (DT):
8.47 d
Key result
Rate constant:
growth rate constant (d-1)
Value:
0.014
Key result
Rate constant:
overall depuration rate constant (d-1)
Value:
0.272
Key result
Rate constant:
growth-corrected depuration rate constant (d-1)
Value:
0.258
Validity criteria fulfilled:
yes
Conclusions:
The kinetic biomagnification factor BMFK was = 0.00261. The lipid and growth normalized biomagnification factor BMFKgL was 0.00637.

Description of key information

.

Key value for chemical safety assessment

BCF (aquatic species):
0.5 dimensionless
BMF in fish (dimensionless):
0.006

Additional information

There are only (Q)SAR data available for this endpoint. Tge 8Q)SAR data are supoirted by environmental measurements of MSCA. There was no dioctlytin detected nor in limnic or marine biiota neither in human.