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Diss Factsheets
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EC number: 481-870-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do no effect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Study design
- Analytical method:
- photometric method
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- < -4.37
- Temp.:
- 23 °C
- pH:
- 7
- Details on results:
- The partition coefficient of the test material has been determined to be <4.31 x 10-5 at 23.0 ± 0.5 degC, log10 Pow <-4.37.
Any other information on results incl. tables
Results
Preliminary estimate
Approximate solubility in n-octanol: 9.2 x 10 -3 g/l
Approximate solubility in water:
>515 g/l
Approximate Pow: 1.79 x 10ResultsPreliminary
estimateApproximate solubility in n-octa-5
Log10Pow: -4.75
Definitive test
The absorbances obtained for the standard, stock and sample solutions are shown in the following two tables:
Organic Phase
Solution |
Absorbance* |
Standard 0.226 mg/l |
1.720 x 10-3 |
Standard 0.452 mg/l |
3.790 x 10-3 |
Standard 0.510 mg/l |
4.790 x 10-3 |
Standard 0.678 mg/l |
7.350 x 10-3 |
Standard 0.904 mg/l |
9.770 x 10-3 |
Standard 1.13 mg/l |
1.403 x 10-2 |
Sample 1 |
-0.00176993 |
Sample 2 |
-0.00171993 |
Sample 3 |
-0.00157973 |
Sample 4 |
-0.00190003 |
Sample 5 |
-0.00184003 |
Sample 6 |
-0.00198003 |
* corrected for organic blank (water saturated n-octanol:dimethylsulfoxide (1:1))
Aqueous Phase
Solution |
Absorbance |
Standard 10.2 mg/l |
0.390 |
Standard 10.3 mg/l |
0.382 |
Sample 1 |
0.400 |
Sample 2 |
0.396 |
Sample 3 |
0.390 |
Sample 4 |
0.390 |
Sample 5 |
0.393 |
Sample 6 |
0.383 |
Stock solution A |
0.382 |
Stock solution B |
0.391 |
* corrected for organic blank (water saturated n-octanol:dimethylsulfoxide (1:1))
The total weights (mg) and analysed concentration (mg/l) of the respective phases are shown in the following table:
Sample Number |
Volume of Water Saturated n-octanol (ml) |
Volume of Stock Solution (ml) |
Total Weight (mg)* |
Organic Phase |
Aqueous Phase |
|||
Analysed Concentration (mg/l) |
Weight (mg)† |
Analysed Concentration (mg/l) |
Weight (mg)† |
pH |
||||
1 |
110 |
11 |
113 |
0.438 |
4.82 x 10-2 |
1.06 x 104 |
117 |
7.2 |
2 |
110 |
11 |
113 |
0.438 |
4.82 x 10-2 |
1.05 x 104 |
115 |
7.3 |
3 |
110 |
22 |
225 |
0.438 |
4.82 x 10-2 |
1.03 x 104 |
227 |
7.2 |
4 |
130 |
26 |
266 |
0.438 |
5.69 x 10-2 |
1.03 x 104 |
269 |
7.4 |
5 |
110 |
44 |
451 |
0.438 |
4.82 x 10-2 |
1.04 x 104 |
458 |
7.4 |
6 |
110 |
44 |
451 |
0.438 |
4.82 x 10-2 |
1.02 x 104 |
447 |
7.2 |
pH of n-octanol saturated
water: 7.5
pH of stock solution: 7.4
Temperature: 23.0 ± 0.5°C
The partition coefficient determined for each sample is shown in the following table:
Sample Number |
n-Octanol/Water Volume Ratio |
Partition Coefficient |
Log10Pow |
1 |
10 : 1 |
4.13 x 10-5 |
-4.38 |
2 |
4.17 x 10-5 |
-4.38 |
|
3 |
5 : 1 |
4.24 x 10-5 |
-4.37 |
4 |
4.24 x 10-5 |
-4.37 |
|
5 |
5 : 2 |
4.20 x 10-5 |
-4.38 |
6 |
4.31 x 10-5 |
-4.37 |
Overall Pow :4.31 x 10-5 log10Pow: <-4.37
* from analysis of the stock solution
† from analysis of the respective phase
Validation
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 20 mg/l for the aqueous samples. This was satisfactory with a correlation coefficient of 1.00 being obtained.
Discussion
The limit value for the organic phase samples was obtained from the lowest detectable standard within the experimentally determined linearity of response range.
Substances having a log10Powof greater than 3 are regarded as having the potential to bioaccumulate in the environment.
The test material contained benzene sulphonic acid sodium salt groups and therefore pKa values outside the environmentally relevant pH range for the determination of partition coefficient. As a result of this, testing was performed at pH 7 using the shake-flask method as recommended for salts.
Conclusion
The partition coefficient of the test material has been determined to be 4.31 x 10-5at 23.0 ± 0.5°C, log10Pow -4.37.
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of the test material has been determined to be <4.31 x 10-5 at 23.0 ± 0.5°C, log10 Pow <-4.37.
- Executive summary:
The determination for substance C-M5 in project number 0345 -0889 was carried out using the shake-flask method, Method A8 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC), Method 107 of the OECD Guidelines for Testing of Chemicals, 27 July1995.The partition coefficient of the test material has been determined to be <4.31 x 10-5at 23.0 +/- 0.5 ˚c, log10 Pow <-4.37.
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