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EC number: 231-105-1 | CAS number: 7439-96-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: sub-chronic inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed to good scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Bioaccumulation and locomotor effect of manganese dust in rats
- Author:
- St-Pierre A, Normandin L, Carrier G, Kennedy G, Butterworth R and Zayed J
- Year:
- 2 001
- Bibliographic source:
- Inhal Toxicol 13:623-632
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 3.75 mg Mn/m3 (respirable) exposure 6h/day 5 days/wk for 13 weeks. Blood chemistry + organ weights measured
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Manganese
- EC Number:
- 231-105-1
- EC Name:
- Manganese
- Cas Number:
- 7439-96-5
- Molecular formula:
- Mn
- IUPAC Name:
- manganese
- Details on test material:
- Metallic Mn (99% pure, Aldrich Chemical Company, Inc., Milwaukee, WI
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Canana Inc. Milwaukee, WI
- Weight at study initiation: 180-200 g
- Fasting period before study: none
- Housing:stainless steel cages
- Diet: Ad libitum
- Water: Ad libitum
- Acclimation period: 3 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-22
- Photoperiod (hrs dark / hrs light):12:12
Administration / exposure
- Route of administration:
- inhalation: dust
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- 5 days/wk, 6 h/day.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Nominally 3.75 mg/m3
Basis:
other: Air samples were collected in both chambers on a daily basis. Gilian pumps (Gilian Corp., West Caldwell, NJ) with standard three-piece cassettes were used for sampling. The filters were Teflon (manufactured for SKC, Inc., Gelman Sciences, Ann Arbor, MI) w
- No. of animals per sex per dose:
- 26
- Control animals:
- other: Exposed to 0.004 mg/m3 Mn (respirable)
Examinations
- Neurobehavioural examinations performed and frequency:
- Following the 13 wks of exposure, locomotor activity was measured using a computerized autotrack system (Columbus Instruments, OH) as
NEUROTOXICOLOGY OF MANGANESE 625 reported by Therrien et al. (1995). The locomotor activity testing included day–night (or light–dark) rhythms and exploratory activity. Animal activity meters were used and installed in a quiet, isolated room with 12-h light/dark cycles. Individual activity profiles for each rat over the 12-h light/dark periods and cumulative activity scores for a period of 36 h were measured as described by Therrien et al. (1995). During this period, food and water were available ad libitum. - Sacrifice and (histo)pathology:
- Mn concentrations in organs and blood were determined by INAA. In order to examine in an exploratory way any dysfunction (such as kidney or renal failure) related to Mn exposure, the following biochemical tests were performed by standard techniques: blood hematocrit, blood glucose, blood urea nitrogen (BUN), serum creatinine, bilirubin, transaminases (aspartate aminotransferase, AST; alanine aminotransferase, ALT), alkaline phosphatase, and serum ion
- Statistics:
- Independent t-test.
Results and discussion
Results of examinations
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Clinical biochemistry findings:
- effects observed, treatment-related
- Description (incidence and severity):
- significant decrease of potassium (p < 0.05) and alkaline phosphatase blood concentrations (p < 0.01). Mn concentrations in lung, putamen and cerebellum were significantly higher in E than in C (p < 0.01), as well as in the kidney, frontal cortex, and gl
- Behaviour (functional findings):
- effects observed, treatment-related
- Description (incidence and severity):
- Distance travelled during night time was significantly higher (p < 0.01) than during day time for the two nights and for both C and E groups. On the other hand, resting time was significantly higher (p <0.01) during the day for both groups
Applicant's summary and conclusion
- Conclusions:
- The single concentration of 3.75 mg/m3 respirable Mn appeared to show some effect on locomotor activity in rat. However, no dose-response relationship could be established since only one concentration level was used. Therefore no conclusion can be reached with regards to neurofunctional effects of Mn metal dust via inhalation.
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