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Diss Factsheets
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EC number: 235-186-4 | CAS number: 12125-02-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Reliability adopted from OECD SIDS document - Meets generally accepted scientific standards and acceptable for assessmnet (original literature not available)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- SIDS Initial Assessment Report For SIAM 17 - Ammonium Chloride (12125-02-9)
- Author:
- OECD SIDS
- Year:
- 2 004
- Bibliographic source:
- OECD - submitted on Janaury 30th 2004
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Register, vol.43, no 163
- Version / remarks:
- 1978-08-22
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ammonium chloride
- EC Number:
- 235-186-4
- EC Name:
- Ammonium chloride
- Cas Number:
- 12125-02-9
- Molecular formula:
- ClH4N
- IUPAC Name:
- ammonium chloride
1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Lot No.of test material: 50820
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Rich-Glo-farms (U.S.D.A. 74-AA-29), El Campo, Texas USA
- Housing: Individually in galvanized steel cages placed over trays.
- Diet: ad libitum, Purena Complete Rabbit Chow, Lot #197C and City of Houston
- Water: ad libitum, tap water
- Acclimation period: 21 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22.2 - 24.4
- Humidity (%): 40 - 60
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: Shaved and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 g
- Type of application: the test substance was applied to gauze pads which had been moistened with 1 mL distilled-deionized water
- Restrainers: Yes - Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 4 days
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Application: Two site/animal were exposed to the test substance
- Area of exposure: 1 x 1 cm
- Type of wrap if used: a polyethylene wrapper (secured with masking tape)
REMOVAL OF TEST SUBSTANCE
- Washing: No. (Test site was brushed clean)
SCORING SYSTEM: The skin was scored according to the method of Draize (see below).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: Worst case scenario based on the results reported.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: Worst case scenario based on the results reported.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: Worst case scenario based on the results reported.
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: Worst case scenario based on the results reported.
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: Worst case scenario based on the results reported.
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: Worst case scenario based on the results reported.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of all six animals (12 test sites)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Unabraded skin (12 test sites): 7 test sites were scored with a draize score of 2 while 5 test sites had a draize score of 3, 24 hours after removal of the test patch. These changes were not observed after 48, 72, 96 hours. No edema or eschar was found at any observation time point.
Abraded skin was also scored. (These values however are not included in the final assessment of skin irritation potential of the test substance).
- abraded (12 test sites; 24 hour observation time point): Erythema score of 2 at 7 sites, and an erythema score of 3 was recorded at 5 sites. These changes were not observed after 48, 72, 96 hours. No edema or eschar was found at any observation time point.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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