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EC number: 206-557-8 | CAS number: 354-33-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.1 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 1 mg/L
Marine water
- Hazard assessment conclusion:
- no data: aquatic toxicity unlikely
STP
- Hazard assessment conclusion:
- no emission to STP expected
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.6 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- no exposure of sediment expected
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no exposure of soil expected
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
The aquatic PNECs were estimated by considering the lowest value obtained for structural analogues (LC50 > 100 mg/l for HFC 245fa in fish) and dividing it for the default assessment factors of 1000 for freshwater and 100 for intermittent release. As the POD is not indicative of a real LC50, derived PNECs can be considered as very conservative values.
Sediment toxicity: PNEC was estimated via the Equilibrium partitioning method (Guidance IR&CSA, R.10). The calculated Koc of 20 L/Kg was used for the estimation of the sediment-water partition coefficient Kp-sed in the equation:
Kp-sed= 0.05 * Koc = 1 L/Kg
Ksed-water was calculated in the equation:
Ksed-water = Fwater-sed + F soil-sed * (Kp-sed*2.5) = 0.8 + 0.2 * (3.05*2.5) = 1.3
and used for the PNEC estimation in the equation:
PNECsed = (Ksed-water/1.15) * PNECwater = 0.11 mg/kg w.wt. for fresh water. This PNEC can be converted to the values for dry weight sediment, by dividing for the fraction of solid in the sediments (0.2), to give the reported PNECs.
STP: No emission in STP is expected. PNEC derivation is not necessary for this compartment.
Terrestrial toxicity: No direct or indirect exposure to HFC 125 is expected for terrestrial organisms.
No PNEC derivation is necessary.
Oral (secondary poisoning): due to the very low bioaccumulation potential of HFC 125, no secondary poisoning is to be expected. PNEC derivation is not necessary.
Conclusion on classification
No data are available for HFC 125. However, the comparison with other structurally related HFCs showed that no aquatic acute ecotoxicity is to be expected at concentrations ≤ 100 mg/l. Besides, due to the environmental behaviour of those substances, a very low partitioning into the aquatic environment is predictable. Based on all available data on structural analogues for daphnids, fish and algae, HFC 125 is not classifiable as hazardous to the aquatic environment. As HFC 125 does not contain Chlorine or Bromine, it is not classifiable as dangerous for the ozone layer. In conclusion, no classification for environmental endpoints is deemed necessary for HFC 125 under Directive 67/548/EEC and Regulation (EC) No. 1272/2008.
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