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EC number: 231-768-7 | CAS number: 7723-14-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to GLP and international guidelines, well documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Version / remarks:
- adopted 22 July 2010
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- ferro phosphorus
- IUPAC Name:
- ferro phosphorus
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): ferro phosphorus
- BET (surface area): 0.193 m2/g
- Composition of test material, percentage of components: 63,9 % Fe, 24,66 % P
- Supplier: Luxalloy SA, 10B rueJean Steichen, L-5868 Alzingen, Luxembourg
- Lot: Brixham 12-0157
- Batch nr: 55380-B2
- V_Certificate of analysis: 9 oct 2012
Constituent 1
Test solutions
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: due to the low aqueous solubility of ferro phosphorus, a stock solution was not prepare. Test solutions were prepared by the direct addition of a known weight of Ferro phosphorus to a total volume of 100 mL reverse osmosis (RO) water, synthetic sewage and activated sludge.
REFERENCE SUBSTANCE
- A nominal 100 mg/L stock solution of the reference substance 3,5-dichlorophenol was prepared in RO water. This stock solution was observed to be clear and colourless and its pH was 5.8 and subsequently adjusted to 7.7 with 2M NaOH before use.
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Source: Totnes Sewage Works, Totnes, Devon, UK
- Method of cultivation: inoculum received 1 day prior to the exposure of test and reference substances.
- Pretreatment: the activated sludge was settled and the supernatant decanted. The settled sludge was fed with 50 mL of OECD synthetic sewage feed per litre of sludge per day and aerated at room temperature, until it was used in the test. The total filterable solids concentration was determined on the day of the test and was found to be 7141 mg/L. The pH was measured as 7.1
Study design
- Total exposure duration:
- 3 h
Test conditions
- Test temperature:
- 20 +/- 2°C
- Nominal and measured concentrations:
- Nominal: 10, 100 and 1000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Aeration: yes. aeration at 20 +/- 2°C for 3 hours.
- Concentrations in triplicate
- No. of vessels per control (replicates): 2 control culture flasks
- No of batches: flasks were set up in batches of six. Each batch included a control flask and five test or reference substance flasks.
- 5 flasks containing the reference substance at nominal concentrations 2, 5, 10 and 32 mg/L
- 1 abiotic flask at 32 mg/L
- Each flask contained an excess of the synthetic sewage, sufficient activated sludge to five final solids concentrations of 1500 mg/L (with exception of the abiotic flask), an appropriate quantity of ferro phosphorus and 3,5-dichlorophenol stock solution and RO water to give a final flask contents volume of 100 mL.
- The pH in the flasks was measured at the start and end of the test. Temperature was measured at the end of the 3h aeration.
EXPERIMENTAL DESIGN
- the respiration rate was measured after 3h and compared with the mean respiration rate of the two control cultures. The rate of oxygen uptake was measured in glass sample tubes into which microcathode oxygen electrodes were inserted. The rates of oxygen uptake was expressed as mg/L/h. - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol as recommended in the OECD guideline (ref 1)
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- ferro phosphorus
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- other: EC20
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- ferro phosphorus
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- other: EC80
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- ferro phosphorus
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- ferro phosphorus
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- all test concentrations (flasks with ferro phosphorus) showed inhibition less than 10 %
- Results with reference substance (positive control):
- The reference substance caused substantial inhibition of the respiration rate of the activated sludge. The 3h EC50 value was estimated to be 11 mg/L, within the expected normal range of 2 to 25 mg/L, indicating the sludge was responding normally and confirming the viability of the sludge organisms.
- Reported statistics and error estimates:
- - the EC50 value was estimated by computer software
Applicant's summary and conclusion
- Conclusions:
- The 3h NOEC is 1000 mg/L ferro phosphorus
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