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EC number: 234-933-1 | CAS number: 12042-91-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 June 1979 - 12 July 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Information on substance identity is not based on 12042-91-0. Composition is not available. NON - Guideline study. Non- GLP. Statement from company owner is received on substance identity and composition mentioned in study report. Based on this the reliability turned into 2.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- test material certificate of analysis not included
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): Locron P
- Physical state: Solid
- Molecular formula (if other than submission substance): Al2(OH)5Cl.2-3H2O
Constituent 1
- Specific details on test material used for the study:
- - Storage condition of test material: in the dark at 20 degrees celsius
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- SPF-Wistar (Hoe: WISKf(SPF71))
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund, SPF-Zucht
- Age at study initiation: 8 - 10 weeks
- Weight at study initiation: 182 - 191 g
- Fasting period before study: Not reported
- Housing: individual Makrolon cages with wood shavings
- Diet: Rattendiät Altromin 1324 (ad libitum)
- Water: tap water, in plastic bottle (ad libitum)
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 (+/- 2) °C
- Humidity (%): 50 (+/- 10) %
- Air changes (per hr): partially air-condioned rooms
- Photoperiod (hrs dark / hrs light): Not reported
IN-LIFE DATES: From: To: Not reported
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Remarks:
- deionised
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 30 cm²
- % coverage: aluminium foil (6 x 8 cm) additional elastic plaster bandage
- Type of wrap if used: occlusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes. the treated skin area was rinsed with lukewarm water to remove the remaining test substance
- Time after start of exposure: 24h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 5 mL
- Concentration (if solution): 40% suspension
- Constant volume or concentration used: yes
VEHICLE: deionised water - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 6 female rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 21 days
- Frequency of weighing: weekly
- Necropsy of survivors performed: yes. At the end of the observation period, the surviving experimental animals were killed by CO2 gas, dissected and examined for macroscopically visible changes.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- None
- Clinical signs:
- other: No symptoms of poisoning were observed at any time during the follow-up period
- Gross pathology:
- The macroscopic assessment of the animals killed at the end of the observation period revealed that all animals had a lung with dark red spots (= increased blood-flow). Experience has shown that this finding is not substance-related and results from the method of asphyxiation used.
Any other information on results incl. tables
For raw data, see attached full study report
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the test conditions, the acute dermal LD50 of Locron P towards female Wistar rats is > 2000 mg/kg bw. Therefore, it is not classified according to the annex VI of the Regulation (EC) No. 1272/2008 (CLP) and to the GHS.
- Executive summary:
In an acute dermal toxicity study according to methodology comparable to OECD Guideline 402, 6 female Wistar rats were exposed to Locron P at 2000 mg/kg bw during 24 hours. After the exposure period, the dressing was removed and the treated skin area was rinsed with lukewarm water to remove the remaining test substance. At the end of the observation period, the surviving experimental animals were killed by CO2 gas, dissected and examined for macroscopically visible changes.
No mortality and no clinical signs were observed during the observation period.
Dark red spots in lung (= increased blood-flow) were observed in all animals. Experience has shown that this finding is not substance-related and results from the method of asphyxiation used.
LD50 was found to be > 2000 mg/kg bw
Under the test conditions, the acute dermal LD50 of test substance Locron P is higher than 2000 mg/kg bw. Therefore, the test substance is not classified according to the annex VI of the Regulation (EC) No. 1272/2008 (CLP) and to the GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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