Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 229-176-9 | CAS number: 6422-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24-hour exposure followed by 14 day observation period
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted prior to introduction of Good Laboratory Practices; data from a summary report; limited number of animals. Study was conducted by an internal Eastman Kodak Company method, developed prior to established guidelines. The results of this study are valid for classification insofar as the conditions of exposure are at least as stringent as modern guidelines.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not specified
- Principles of method if other than guideline:
- Method is an in vivo study using three guinea pigs. Following depilation of the abdomen of each animal, a single dose of the test substance is applied under an occlusive wrap for 24 hours. Animals are observed following removal of the cuff, and on Days 7 and 14. In addition to observations for mortality, dermal reactions and weight changes were also recorded.
- GLP compliance:
- no
- Remarks:
- Study conducted prior to GLPs
- Test type:
- other: internal Eastman Kodak method
- Limit test:
- no
Test material
- Reference substance name:
- Bis(2-ethylhexyl) terephthalate
- EC Number:
- 229-176-9
- EC Name:
- Bis(2-ethylhexyl) terephthalate
- Cas Number:
- 6422-86-2
- Molecular formula:
- C24H38O4
- IUPAC Name:
- 1,4-bis(2-ethylhexyl) benzene-1,4-dicarboxylate
- Reference substance name:
- Reference substance 001
- Cas Number:
- 6422-86-2
- Details on test material:
- -Test substance (as cited in report): Bis (2-ethylhexyl) terephthalate
Constituent 1
Constituent 2
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Test animals:
-Weight at study initiation: 535 - 575 g
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Following depilation of each animal's abdomen, a single dose of 5.0, 10.0, or 20.0 mL/kg bw of the test substance was applied under an occlusive cuff and wrap. This is equivalent to 4920, 9840 or 19,680 mg/kg bw based on the density (0.984 g/cm3) of the undiluted test material. After a 24-hour exposure period, the cuffs and wrappings were removed.
- Duration of exposure:
- 24 hours
- Doses:
- 5.0, 10.0, and 20.0 mL/kg bw
- No. of animals per sex per dose:
- 1 animal/dose (sex not specified)
- Control animals:
- no
- Details on study design:
- Three guinea pigs (sex, age, and initial weights not provided) were used. Following depilation of the guinea pig abdomens, a single dose of 5.0, 10.0, or 20.0 mL/kg bw of the test substance was applied under an occlusive wrap prepared from a pad of gauze held in place with an impervious cuff made of rubber dental dam material. The cuff was wrapped securely around the torso of the guinea pig and held in place with non-irritating tape. Animals were exposed for 24 hours, then the cuffs were removed. Animals were observed following removal of the cuff, and on Days 7 and 14. In addition to observations for mortality, dermal reactions were also noted. Guinea pigs were weighed prior to administration of the test substance and at termination of the 14-day observation period.
- Statistics:
- not performed
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 20 mL/kg bw
- Mortality:
- None
- Clinical signs:
- other: No signs of test material absorption or systemic toxicity were noted during the study. Signs of irritation at the application site were limited to moderate to gross edema (24 hours) and slight desquamation (7 and 14 days).
- Gross pathology:
- not performed
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- Three guinea pigs were exposed to the test substance at dose levels of 5, 10, or 20 mL/kg bw for 24 hours under an occlusive cuff. The dermal LD50 in guinea pigs was > 20.0 mL/kg bw (equivalent to 19,680 mg/kg bw).
Based on an acute dermal LD50 value of greater than 20 mL/kg bw in guinea pigs, di (2-ethylhexyl) terephthalate is not classified as a toxicant for classification and labeling for acute lethality by the dermal route according to GHS. - Executive summary:
In an acute dermal toxicity study, 3 guinea pigs were exposed for 24 hours under occlusive contact to 5, 10 or 20 mL/kg bw of di (2-ethylhexyl) terephthalate. Under the conditions of this study, no deaths occurred and the dermal LD50 was considered to be > 20.0 mL/kg bw. No signs of skin absorption or systemic toxicity were evident during the study. At the application sites, signs of irritation caused by the solvent included moderate to gross edema at 24 hours, and slight desquamation at both 1 and 2 weeks after test substance administration. A body weight gain was noted in all animals over the 2-week observation period. Based on the results of this study, di (2-ethylhexyl) terephthalate presents a low toxicity hazard but may cause significant irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.