Registration Dossier
Registration Dossier
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EC number: 232-089-9 | CAS number: 7785-87-7
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Manganese induced hepatic lesions in carbon tetrachloride pretreated rats
- Author:
- Chandra SV and Saxena dK
- Year:
- 1 975
- Bibliographic source:
- Exp Path Bd, 10: 285-288
Materials and methods
- Principles of method if other than guideline:
- Manganese sulphate was administered intraperitoneally daily for 30 days in carbon tetrachloride pretreated rats.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- manganese sulphate tetrahydrate
- IUPAC Name:
- manganese sulphate tetrahydrate
- Details on test material:
- MnSO4.4H2O
Constituent 1
Results and discussion
Any other information on results incl. tables
Histological and histochemical studies in liver tissue revealed extensive damage to hepatic parenchyma in these rats as compared to lesions produced by manganese sulphate alone.
Applicant's summary and conclusion
- Conclusions:
- These findings suggest that workers, with liver dysfunction engaged in the manganese industry may be more susceptible to the toxic effects of this metal.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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