Silicon tetrachloride

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

No data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Version / remarks:

Test was conducted prior to adoption of test guideline

Deviations:

yes

Remarks:

One animal per dose, used to measure minimum lethal dose rather than LD50, no necropsy as no animals died, no test substance or animal environmental condition details.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Silicon tetrachloride

EC Number:

233-054-0

EC Name:

Silicon tetrachloride

Cas Number:

10026-04-7

Molecular formula:

Cl4Si

IUPAC Name:

tetrachlorosilane

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Details on test animals or test system and environmental conditions:

No data given

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: No data
- % coverage: No data
- Type of wrap if used: Occlusive


REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data
- Time after start of exposure: No data


TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1000, 1580, 2510, 3980, 6310, 10000 mg/kg bw

Duration of exposure:

24 hours

Doses:

1000, 1580, 2510, 3980, 6310, 10000 mg/kg bw

No. of animals per sex per dose:

1 animal/dose (both male and female animals were used)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 5 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No
- Other examinations performed: None

Statistics:

No statistics performed

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD0

Effect level:

>= 10 000 mg/kg bw

Mortality:

The highest application of 10000 mg/kg was not found to be lethal by dermal exposure.

Clinical signs:

other: Symptoms included marked discomfort and moderate weakness at the higher dosage levels. 

Gross pathology:

None conducted

Other findings:

None reported

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In the acute dermal toxicity study, conducted according to a protocol similar to OECD Test Guideline 402 but pre-GLP, no mortalities occurred and an LD50 of >10,000 mg/kg bw was concluded.