Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-034-8 | CAS number: 16961-83-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biological effects monitoring
Administrative data
- Endpoint:
- biological effects monitoring
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: mesocosm study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Integrated criteria document fluorides
- Author:
- Janssen PJCM, Janus JA, Knaap AGAC
- Year:
- 1 989
- Bibliographic source:
- National Institute of Public Health and Environmental Protection Bilthoven, The Netherlands, Appendix to report no. 758474010
Materials and methods
- Principles of method if other than guideline:
- In an outdoor estuarine model ecosystem with mud, eelgrass, juvenile pawns and shrimp, the mud crap and fish exposure to an average concentrationof 52 mg F-/L resulted in increased mortality of the crad an the fish and appeared to affect the reproduction of the shrimp. No other concentrations were used in that test (Hemens and Warwick 1972). In two other experiments lower fluoride concentrations were tested in this model ecosystem, using the same organisms except the shrimp. In the first experiment no adverse effect on survival was found at 5.9 mg F-/L after 10 weeks of exposure with exception of a significantly reduced growth rate of the smallest of the two size classes of fish used. In the second experiment no adverse effects were on survival and growth were found at 5.7 mg F-/L after 16 weeks of exposure with exception of some mortality (16%, statistically not significant) among te exposed fish. In both tests no other concentrations were used.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium fluoride
- EC Number:
- 231-667-8
- EC Name:
- Sodium fluoride
- Cas Number:
- 7681-49-4
- Molecular formula:
- FNa
- IUPAC Name:
- sodium fluoride
1
- Specific details on test material used for the study:
- The fluoride concentration was reported. Since no reference substance exists for fluoride ions, the reference substance was set to sodium fluoride.
Results and discussion
Any other information on results incl. tables
In an outdoor estuarine model ecosystem with mud, eelgrass, juvenile pawns and shrimp, the mud crab and fish exposure to an average concentration of 52 mg F-/L resulted in increased mortality of the crab an the fish and appeared to affect the reproduction of the shrimp. No other concentrations were used in that test (Hemens and Warwick 1972). In two other experiments lower fluoride concentrations were tested in this model ecosystem, using the same organisms except the shrimp. In the first experiment no adverse effect on survival was found at 5.9 mg F-/L after 10 weeks of exposure with exception of a significantly reduced growth rate of the smallest of the two size classes of fish used. In the second experiment no adverse effects were on survival and growth were found at 5.7 mg F-/L after 16 weeks of exposure with exception of some mortality (16%, statistically not significant) among the exposed fish. In both tests no other concentrations were used.
Applicant's summary and conclusion
- Executive summary:
In an outdoor estuarine model ecosystem with mud, eelgrass, juvenile pawns and shrimp, the mud crap and fish exposure to an average concentrationof 52 mg F-/L resulted in increased mortality of the crad an the fish and appeared to affect the reproduction of the shrimp. No other concentrations were used in that test (Hemens and Warwick 1972). In two other experiments lower fluoride concentrations were tested in this model ecosystem, using the same organisms except the shrimp. In the first experiment no adverse effect on survival was found at 5.9 mg F-/L after 10 weeks of exposure with exception of a significantly reduced growth rate of the smallest of the two size classes of fish used. In the second experiment no adverse effects were on survival and growth were found at 5.7 mg F-/L after 16 weeks of exposure with exception of some mortality (16%, statistically not significant) among the exposed fish. In both tests no other concentrations were used.
The NOEC is considered to be 5.7 mg F-/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.