Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-688-8 | CAS number: 2867-47-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (non-GLP, no details on test substance incl. purity, only 2-hour reading, short observation period).
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Reference Type:
- publication
- Title:
- Atochem (1980), Skin and Ocular Irritation test, Consultox Lab: CL80 65:2030
- Author:
- Atochem
- Year:
- 2 003
- Bibliographic source:
- cited in: OECD SIDS, 2-Dimethylaminoethylmethacrylate, CAS No: 2867-47-2, 07/2003
Materials and methods
- Principles of method if other than guideline:
- According to the method described in the Federal Hazardous Substances Labelling Act Regulations, Section 191.11, published in the Federal Register - 29 F.R. 13009, 1964.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-dimethylaminoethyl methacrylate
- EC Number:
- 220-688-8
- EC Name:
- 2-dimethylaminoethyl methacrylate
- Cas Number:
- 2867-47-2
- Molecular formula:
- C8H15NO2
- IUPAC Name:
- 2-(dimethylamino)ethyl methacrylate
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No details.
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 mL
- Concentration: undiluted - Duration of treatment / exposure:
- 2 hours
- Observation period (in vivo):
- 2 hours
- Number of animals or in vitro replicates:
- 2 females
- Details on study design:
- 0.1 mL of the test substance was instilled into one eye of each animal. The lids were gently held together for one second and the eye was then rinsed
with 20 mL Iukewarm water at 4 seconds after instillation. The eyes were examined 2 hrs after instillation. The scoring system used was that according to Draize.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3.5
- Max. score:
- 4
- Reversibility:
- other: not examined
- Remarks on result:
- other: The observation period was too short for a clear conclusion on the reversibilty of the irritation parameters (termination of study 2 hours after administration of the test substance).
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 2 hours
- Score:
- 3
- Reversibility:
- other: not examined
- Remarks on result:
- other: The observation period was too short for a clear conclusion on the reversibilty of the irritation parameters (termination of study 2 hours after administration of the test substance).
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: 2 hours
- Score:
- 4
- Reversibility:
- other: not examined
- Remarks on result:
- other: The observation period was too short for a clear conclusion on the reversibilty of the irritation parameters (termination of study 2 hours after administration of the test substance).
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- other: not examined
- Remarks on result:
- other: The observation period was too short for a clear conclusion on the reversibilty of the irritation parameters (termination of study 2 hours after administration of the test substance).
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 2 hours
- Score:
- 2
- Reversibility:
- other: not examined
- Remarks on result:
- other: The observation period was too short for a clear conclusion on the reversibilty of the irritation parameters (termination of study 2 hours after administration of the test substance).
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: 2 hours
- Score:
- 2
- Reversibility:
- other: not examined
- Remarks on result:
- other: The observation period was too short for a clear conclusion on the reversibilty of the irritation parameters (termination of study 2 hours after administration of the test substance).
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- other: not examined
- Remarks on result:
- other: The observation period was too short for a clear conclusion on the reversibilty of the irritation parameters (termination of study 2 hours after administration of the test substance).
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 2 hours
- Score:
- 3
- Reversibility:
- other: not examined
- Remarks on result:
- other: The observation period was too short for a clear conclusion on the reversibilty of the irritation parameters (termination of study 2 hours after administration of the test substance).
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 2 hours
- Score:
- 3
- Reversibility:
- other: not examined
- Remarks on result:
- other: The observation period was too short for a clear conclusion on the reversibilty of the irritation parameters (termination of study 2 hours after administration of the test substance).
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3.5
- Max. score:
- 4
- Reversibility:
- other: not examined
- Remarks on result:
- other: The observation period was too short for a clear conclusion on the reversibilty of the irritation parameters (termination of study 2 hours after administration of the test substance).
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 2 hours
- Score:
- 3
- Reversibility:
- other: not examined
- Remarks on result:
- other: The observation period was too short for a clear conclusion on the reversibilty of the irritation parameters (termination of study 2 hours after administration of the test substance).
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 2 hours
- Score:
- 4
- Reversibility:
- other: not examined
- Remarks on result:
- other: The observation period was too short for a clear conclusion on the reversibilty of the irritation parameters (termination of study 2 hours after administration of the test substance).
- Irritant / corrosive response data:
- Despite the rinsing treatment severe corneal, iris and conjunctival lesions were displayed by both animals within 2 hrs of instillation. The test was
terminated at this point. lt is reasonable to assume that similar levels of injury would be produced if full scale testing were conducted, and that the
product would be classified as corrosive to the eye.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- It is reasonable to assume that similar levels of injury would be produced if full scale testing were conducted, and that the product would be classified as corrosive to the eye.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.