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Diss Factsheets
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EC number: 202-496-6 | CAS number: 96-29-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Two short-term toxicity studies with freshwater fish are available for MEKO. A 96-h LC50 value of >100 mg/L, obtained in a GLP-compliant, OECD Guideline 203 study with Oryzias latipes conducted under semi-static conditions with analytical monitoring (Kurume Laboratory, 1998a) will be used in the assessment.
Two short-term toxicity studies with aquatic invertebrates are available for MEKO. The lowest 48-h EC50 of ca. 201 mg/L in Daphnia magna was obtained in a static GLP-compliant, OECD 202 guideline study with analytical monitoring (Kurume Laboratory, 1998c). This value will be used in the assessment.
Two growth inhibition studies with freshwater algae are available for MEKO. A 72-h NOErC of 2.56 mg/L and a 72-h ErC50 of 11.8 mg/L, obtained in a static GLP-compliant OECD Guideline 201 test with Scenedesmus capricornutum (Kurume Laboratory, 1998e), performed with analytical monitoring, are used in the assessment.
One long-term toxicity study with freshwater fish is available for MEKO. The test is a flow-through GLP-compliant, OECD Guideline 204 study with Oryzias latipes with analytical monitoring (Kurume Laboratory, 1998b). The 14-d NOEC is >100 mg/L based on mortality. This value will be used in the assessment.
In a long-term toxicity test with aquatic invertebrates, a semi-static GLP-compliant OECD Guideline 211 test with analytical monitoring (Kurume Laboratory, 1998d), a 21-d NOEC of =100 mg/L, based on the reproduction rate, is reported. This value will be used in the assessment.
In a static freshwater microorganism toxicity study with Pseudomonas putida (BASF Ecotoxicology Laboratory, 1988), performed according to BASF protocols, the 17-h EC10 is 177 mg/L, based on growth inhibition. No data are available on the GLP status and analytical monitoring. A LOEC of =630 mg/L was reported in another study (Meinck et al., 1968), for which only information from secondary sources is available. The 17-h EC10 is 177 mg/L in Pseudomonas putida will be used in the assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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