Registration Dossier
Registration Dossier
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EC number: 212-485-8 | CAS number: 822-06-0
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Test chamber exposure of humans to 1,6-hexamethylene diisocyanate and isophorone diisocyanate
- Author:
- Tinnerberg H et al.
- Year:
- 1 995
- Bibliographic source:
- Int. Arch. Occup. Environ. Health 67: 367-374
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- basic toxicokinetics
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hexamethylene diisocyanate
- EC Number:
- 212-485-8
- EC Name:
- Hexamethylene diisocyanate
- Cas Number:
- 822-06-0
- Molecular formula:
- C8H12N2O2
- IUPAC Name:
- 1,6-diisocyanatohexane
Constituent 1
Method
- Route of exposure:
- inhalation
Results and discussion
Any other information on results incl. tables
Three volunteers were each exposed to 11.9, 20.5 and 22.1 µg HDI/m3 for 2 hours. After hydrolysis under alkaline conditions the
average urinary excretion of 1,6-hexamethylene diamine (HDA) was 39 %. The average urinary elimination half-time for HDA was 2.5 hours. No HDA could be found in hydrolysed plasma.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
