Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable, well documented publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Test chamber exposure of humans to 1,6-hexamethylene diisocyanate and isophorone diisocyanate
Author:
Tinnerberg H et al.
Year:
1995
Bibliographic source:
Int. Arch. Occup. Environ. Health 67: 367-374

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
basic toxicokinetics
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexamethylene diisocyanate
EC Number:
212-485-8
EC Name:
Hexamethylene diisocyanate
Cas Number:
822-06-0
Molecular formula:
C8H12N2O2
IUPAC Name:
1,6-diisocyanatohexane

Method

Route of exposure:
inhalation

Results and discussion

Any other information on results incl. tables

Three volunteers were each exposed to 11.9, 20.5 and 22.1 µg HDI/m3 for 2 hours. After hydrolysis under alkaline conditions the 

average urinary excretion of 1,6-hexamethylene diamine (HDA) was 39 %. The average urinary elimination half-time for HDA was 2.5 hours. No HDA could be found in hydrolysed plasma.

Applicant's summary and conclusion