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EC number: 212-449-1 | CAS number: 818-08-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 April 2010 to 11 June 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- cascade impaction
- Remarks on result:
- not determinable
- Percentile:
- D50
- Remarks on result:
- other: Too few particles were of a size less than 10.0 µm to allow accurate assessment of the mass median aerodynamic diameter.
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- 59.6 %
- Remarks on result:
- other: Sieve method
- No.:
- #2
- Size:
- < 10 µm
- Distribution:
- 0.065 %
- Remarks on result:
- other: cascade impactor method
- No.:
- #3
- Size:
- < 5.5 µm
- Distribution:
- 0.049 %
- Remarks on result:
- other: cascade impactor method
- Conclusions:
- Proportion of test item having a thoracic particle size < 10.0 µm = 6.45 x 10^-2 %
Proportion of test item having a respirable particle size < 5.5 µm = 4.89 x 10^-2 % - Executive summary:
Particle size data have been acquired using a procedure designed to comply with the European Commission technical guidance docunt 'Particle Size Distribution, Fibre Length and Diater Distribution' (June 1996), which satisfies the requirents of OECD Guideline 110. The results are as follows:
Measurement
Method
Result
Proportion of test item having an inhalable particle size < 100 µm
Sieve
59.6 %
Proportion of test item having a thoracic particle size < 10.0 µm
Cascade Impactor
6.45 x 10-2 %
Proportion of test item having a respirable particle size < 5.5 µm
Cascade Impactor
4.89 x 10-2 %
Reference
Screening test (sieve method)
The results of the sieving procedure are shown in the following table:
Measurement |
Result |
Mass of test item transferred to sieve |
15.48 g |
Mass of test item passed through sieve |
9.22 g |
Proportion of test item <100 µm |
59.6 % |
Definitive test (cascade impactor method)
The results of the cascade impactor method determinations are shown as follows:
Determination 1
Collection Stage |
ParticleCollected (µm) |
Mass (g) |
||
Pre-sampling |
Post-sampling |
Difference |
||
Cup 1 |
>10.0 |
86.4311 |
89.0490 |
2.6179 |
Cup 2 |
5.5 to 10.0 |
85.7428 |
85.7433 |
0.0005 |
Cup 3 |
2.4 to 5.5 |
86.1810 |
86.1812 |
0.0002 |
Cup 4 |
1.61 to 2.4 |
85.9172 |
85.9176 |
0.0001 |
Cup 5 |
0.307 to 1.61 |
86.0596 |
86.0598 |
0.0002 |
Filter |
<0.307 |
75.6559 |
75.6564 |
0.0005 |
Mass of test item found in artificial throat: 0.37 g
Total mass of test item recovered from artificial throat, sample cups
and filter: 2.9894 g
Determination 2
Collection Stage |
ParticleCollected (µm) |
Mass (g) |
||
Pre-sampling |
Post-sampling |
Difference |
||
Cup 1 |
>10.0 |
86.4342 |
89.4373 |
3.0031 |
Cup 2 |
5.5 to 10.0 |
85.7451 |
85.7457 |
0.0006 |
Cup 3 |
2.4 to 5.5 |
86.1801 |
86.1814 |
0.0013 |
Cup 4 |
1.61 to 2.4 |
85.9170 |
85.9170 |
0.0000 |
Cup 5 |
0.307 to 1.61 |
86.0603 |
86.0604 |
0.0001 |
Filter |
<0.307 |
75.6572 |
75.6581 |
0.0009 |
Mass of test item found in artificial throat: 0.02 g
Total mass of test item recovered from artificial throat, sample cups
and filter: 3.0260 g
Determination 3
Collection Stage |
ParticleCollected (µm) |
Mass (g) |
||
Pre-sampling |
Post-sampling |
Difference |
||
Cup 1 |
>10.0 |
86.4318 |
89.3667 |
2.9349 |
Cup 2 |
5.5 to 10.0 |
85.7435 |
85.7438 |
0.0003 |
Cup 3 |
2.4 to 5.5 |
86.1809 |
86.1817 |
0.0008 |
Cup 4 |
1.61 to 2.4 |
85.9170 |
85.9171 |
0.0001 |
Cup 5 |
0.307 to 1.61 |
86.0605 |
86.0607 |
0.0002 |
Filter |
<0.307 |
75.6597 |
75.6597 |
0.0000 |
Mass of test item found in artificial throat: 0.01 g
Total mass of test item recovered from artificial throat, sample cups
and filter: 2.9463 g
Cumulative amounts
The cumulative amounts of test item found in the three determinations for the individual particle size cut-points (µm) are shown in the following table:
Particle Size Cut-point (µm) |
Cumulative Mass (g) |
Cumulative Percentage (%) |
||||
Determination 1 |
Determination 2 |
Determination 3 |
Determination 1 |
Determination 2 |
Determination 3 |
|
10.0 |
0.0015 |
0.0029 |
0.0014 |
5.02 x 10-2 |
9.58 x 10-2 |
4.75 x 10-2 |
5.5 |
0.0010 |
0.0023 |
0.0011 |
3.35 x 10-2 |
7.60 x 10-2 |
3.73 x 10-2 |
2.4 |
0.0008 |
0.0010 |
0.0003 |
2.68 x 10-2 |
3.31 x 10-2 |
1.02 x 10-2 |
1.61 |
0.0007 |
0.0010 |
0.0002 |
2.34 x 10-2 |
3.31 x 10-2 |
6.79 x 10-3 |
0.307 |
0.0005 |
0.0009 |
0.0000 |
1.67 x 10-2 |
2.97 x 10-2 |
0.00 |
The overall cumulative percentage (%) of test item with a particle size less than 10.0 µm and 5.5 µm are shown in the following table:
Particle size |
Cumulative Percentage (%) |
|||
Determination 1 |
Determination 2 |
Determination 3 |
Mean |
|
<10.0 µm |
5.02 x 10-2 |
9.58 x 10-2 |
4.75 x 10-2 |
6.45 x 10-2 |
<5.5 µm |
3.35 x 10-2 |
7.60 x 10-2 |
3.73 x 10-2 |
4.89 x 10-2 |
Description of key information
Particle size data have been acquired using a procedure designed to comply with the European Commission technical guidance document 'Particle Size Distribution, Fibre Length and Diater Distribution' (June 1996), which satisfies the requirements of OECD Guideline 110.
Results:
Proportion of test item having a thoracic particle size < 10.0 µm = 6.45 x 10^-2 %
Proportion of test item having a respirable particle size < 5.5 µm = 4.89 x 10^-2 %
Additional information
A reliability rating of 1 was assigned to this study, according to the criteria of Klimisch, 1997 as the study was conducted in accordance with a recognised guideline and GLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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