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Diss Factsheets
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EC number: 215-270-7 | CAS number: 1317-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Already evaluated by the Competent Authorities for Biocides and Existing Substance Regulations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- US Federal Hazardous Substances Labeling Act Regulations
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dicopper oxide
- EC Number:
- 215-270-7
- EC Name:
- Dicopper oxide
- Cas Number:
- 1317-39-1
- Molecular formula:
- Cu2O
- IUPAC Name:
- copper (I) oxide
- Details on test material:
- Purity: No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- At the start of the study animals weighed 241 to 271 g. No information was provided on the age of the animals.
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: none
- Details on inhalation exposure:
- The test material was used as supplied.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 1 h
- Concentrations:
- 200 mg/l (nominal)
- No. of animals per sex per dose:
- One group of 10 males
- Control animals:
- no
- Details on study design:
- The animals were weighed before exposure and at the end of the two week observation period. Gross observations were made relative to their well-being and at autopsy.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 200 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- There were no deaths in this study.
- Clinical signs:
- other: Clinical signs were not reported.
- Body weight:
- All test organisms gained weight over the course of the 14 day observation period.
- Gross pathology:
- Upon autopsy, survivors showed no abnormalities of organs of the thorax and abdomen.
- Other findings:
- The results are summarised in Table 1.
Any other information on results incl. tables
Table 1. Acute inhalation toxicity study - summary of findings |
|||
Dose [mg/l] |
Number of dead / |
Time of death (range) |
Observations |
200 (males) |
0/10 |
- |
Clinical signs were not reported. There were no gross necropsy findings. |
LC50(1 h) in the male at > 200 mg/l (nominal concentration) |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In the study, the acute inhalation LC50 (1 h) in the male rat was found to be greater than 200 mg/l (nominal concentration). However this study showed major methodological and reporting deficiencies and the results are therefore considered to be unreliable.
- Executive summary:
Materials and Methods:
This study was not conducted according to GLP and showed major methodological and reporting deficiencies. Deviations from OECD Test Guideline 403 include:
Test material concentrations in the test breathing zone, and particle size distribution were not measured,
The exposure period was only 1 h (compared to 4 hrs recommended in the test guideline),
There is no justification for the use of only male animals,
The following information was not reported:
- The purity of the test substance,
- Strain, age and source of test animals,
- Experimental test and housing conditions of the animals.
The following brief description of the test design was given in the study report:
Ten male rats were placed in an enclosed chamber. The test sample was sprayed into the chamber to yield a concentration of 200 mg/ml in the atmosphere. This concentration was maintained for a period of one hour. Following exposure the animals were held for a period of two weeks. The animals were weighed before exposure and at the end of the two weeks. Gross observations were made relative to well-being and at autopsy.
Results and Discussion:
There were no deaths. Clinical signs were not reported.
Upon autopsy, survivors showed no abnormalities of organs of thorax and abdomen.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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