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Diss Factsheets
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EC number: 202-951-9 | CAS number: 101-54-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Although 4-ADPA is not readily biodegradable with only 8% biodegradation observed in 20 days, it is inherently biodegradable with more than 70% DOC removal observed in 7 days independent from adsorption. 4-ADPA is abiotically stable without presence of light and oxygen. At 25°C the hydrolysis half-lives of 4-ADPA of 42 days at pH 7.0 and 75 days at pH 4 with light excluded were observed. In nutrient medium same as the one used in algal inhibition test, the half-life of 4-ADPA decreased to 3.5 d in presence of light and oxygen. 4-hydroxydiphenylamine and aniline were observed as main metabolites. The obtained half-life of 3.5 d was used to estimate the effective concentrations from nominal concentrations in ecotoxicity studies. On the other hand, 4-ADPA can be completely photocatalytically oxidized in water using TiO2 and/or SnO2 in 3.5 hours. 4-ADPA is not bioaccumulative with an estimated BCF of 7, which is far below 100. Simultaneously, 4-ADPA has a low adsorption potential in soil/sludge with the adsorption coefficient (log Koc) of 2.72. 4-ADPA is essentially non-volatile with an estimated Henry’s Law Constant of 2.8*10-5 Pa m³/mol at 20°C. Meanwhile it has a calculated half-life of 1.92 hours in air due to the reaction with hydroxyl radicals with a rate constant of 2 *10-10 cm3/(molecule*sec). The estimated half-life in air of 4-ADPA is much shorter than 48 hours; and hence no potential for long-range transport of 4-ADPA in air is expected. The distribution of 4-ADPA in a "unit world" was calculated according to the Mackay fugacity model level I based on the physico-chemical properties. The main target compartment for 4-ADPA is water of 98.96 %.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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