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EC number: 292-769-6 | CAS number: 90990-08-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Worst-case EC50 for growth rate > 7.6 mg/L - no effects up to the limit of water solubility are expected.
Key value for chemical safety assessment
Additional information
Studies are available for some pure homologue members of the fatty acid category. In addition some studies are available for certain fatty acid mixtures. Generally it could be stated that toxicity of fatty acids to aquatic organisms increases with increasing chain length up to the water solubility limit at a chain length of C12. For longer chains no effects at saturation are observed.
For the mixture under discussion here no study on algae is available. Thus a read-across is prepared to studies conducted with the pure homologues C12 (CAS 143 -07 -7), C14 (CAS 544 -63 -8) and C16 (CAS 57 -10 -3) some of the main components of the mixture.
For the evaluation of the mixture only studies available for pure homologues which were determined as key were chosen for read-across. All linked studies conducted with the pure homologues were used in a weight of evidence approach to cover the endpoint "toxicity of aquatic algae" for the considered fatty acid mixture.
Fatty acid homologue |
EC50for growth rate (as reported in the study) |
Water solubility* |
Test design and species |
Reference |
C12 - CAS 143-07-7 |
> 7.6 mg/L (initial mean measured) |
4.81 mg/L at 20 °C |
72 h, static, |
NITE, 2001d |
C14 - CAS 544-63-8 myristic acid |
> 2.1 mg/L (measured) |
< 0.13 at 20 °C |
72 h, static, |
NITE, 2003d |
C16 - CAS 57-10-3 palmitic acid |
> 0.9 mg/L (initial mean measured) |
< 0.05 at 20 °C |
72 h, static, |
NITE, 2003b |
* see category justification
In the study available for lauric acid (12: CAS 143 -07 -7), which was conducted according to the OECD guideline 201, algae (Pseudokirchneriella subcapitata) were exposed with the test substance in a dose-response experiment under GLP-conditions (NITE, 2001d). In the static test an EC50 for growth rate > 7.6 mg/L (initial measured) was determined, which is above the reported limit of water solubility for this homologue.
The homologue myristic acid (C14: CAS 544 -63 -8) was tested on Pseudokirchneriella subcapitata in a static limit test according
to OECD 201 in compliance with GLP-requirements (NITE, 2003d). The tested concentration of 2.1 mg/L (measured) was above the limit of water solubility reported in the category justification for the C14 fatty acid homologue (< 0.13 mg/L). As no effects could be observed at this concentration the EC50 for growth rate is reported to be above 2.1 mg/L.
Palmitic acid (C16: CAS 57 -10 -3) was tested on Pseudokirchneriella subcapitata as well under OECD 201 in a GLP-study (NITE, 2003b). As described for the C14 fatty acid homologue, only one test substance concentration was used (10 mg/L nominal, corresponding to 0.9 mg/L initial mean measured), which was above the reported water solubility limit for this substance (< 0.05 mg/L according to the category justification). As no effects could be observed at this test concentration, the EC50 for growth rate is reported to be above 0.9 mg/L (initial mean measured).
From the reported results of the test available for the fatty acid homologues C12, C14 and C16 no adverse effects of the considered fatty acid mixture are expected on algae. In all cited tests no effects up to the water solubility limits of the pure homologues were reported. Thus the EC50 based on growth rate is expected to be > 7.6 mg/L for the fatty acid mixture.
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