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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 June 2009 - 5 October 2009
Reliability:
1 (reliable without restriction)

Data source

Reference
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
not specified
GLP compliance:
not specified
Type of method:
other: Differential Scanning Calorimeter

Test material

Constituent 1
Chemical structure
Reference substance name:
4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
EC Number:
700-455-1
Cas Number:
380843-75-4
Molecular formula:
C26H29Cl2N5O3
IUPAC Name:
4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
Details on test material:
Equipment:
Differential Scanning Calorimeter: TA Instruments 2920 MDSC
Aluminium Sample Pans: TA Instruments 900793.901
Sample pans lids: TA Instruments 900794.901
Analytical Balance: Mettler-Toledo AT 261

Melting point Standards
Indium: Source: LGC2601; Certified Melting Temp.: 156.61ºC
Lead: Source: LGC2608; Certified Melting Temp.: 327.47ºC
Gallium: Source: NIST SRM2234; Certified Melting Temp.: 29.76ºC
Tin: Source: LGC2609 Certified Melting Temp.: 231.92ºC

Results and discussion

Melting / freezing point
Melting / freezing pt.:
>= 136 - <= 145 °C
Remarks on result:
other: Change from a solid to a liquid state.

Applicant's summary and conclusion