Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
19 µg/L
Assessment factor:
1 000
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
190 µg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
1.9 µg/L
Assessment factor:
10 000
Extrapolation method:
assessment factor
PNEC marine water (intermittent releases):
19 µg/L

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
10 mg/L
Assessment factor:
10
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
161.5 µg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
16.15 µg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
21.15 µg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

The relevant LC/EC50 values of acute aquatic toxicity range between 19 mg/L and 47 mg/L for isopropylamine (fish, daphnia, alga).

The amine is readily biodegradable and lacks any potential for bioaccumulation (log Pow <<3; no other indications for bioaccumulataion).

Conclusion on classification

Harmonised classification regarding environmental hazards

Aquatic compartment

According to Regulation (EC) 1272/2008 (CLP) Annex VI Table 3, the submission substance is not classified for environmental hazards.

 

Self-classification according to REGULATION (EC) No. 1272/2008 (CLP)

Following EU-GHS (CLP), the substance is not to be classified as acutely hazardous to the aquatic environment. Based on the available chronic and acute data, the substance is not to be classified as chronically hazardous to the aquatic environment.

Rationale:

The substance is not to be classified as acutely hazardous to the aquatic environment, since the lowest acute effect value is > 1 mg/L.

Chronic data are only available for algae; therefore classification is based on the available chronic and acute toxicity data.

 

- Chronic toxicity data:

Considering the toxicity to aquatic algae, a 72-h EC10 (growth rate) of 2.56 mg/L was determined for isopropylamine. The lowest (only) chronic effect value is > 1 mg/L, indicating that the substance does not present a long-term hazard according to the categories outlined in Table 4.1.0(b) (ii) (Commission Regulation (EU) No 2016/918 of 19 May 2016 amending Regulation (EC) No 1272/2008) for rapidly degradable substances. Therefore, the substance has not to be classified as chronically hazardous to the aquatic environment.

 

- Acute toxicity data:

Classification for chronic endpoints based on acute aquatic toxicity data is performed only in case of not rapidly degradable compounds and/or compounds with an experimentally determined BCF ≥ 500 (or, if absent, log Kow ≥4).

The substance is rapidly biodegradable and the log Kow is < 4 (no experimental BCF available). Therefore, also based on acute data, no chronic classification is applicable for the submission substance.

 

In conclusion, the substance is not to be classified as acutely or chronically hazardous to the aquatic environment.

 

Atmospheric compartment

The test substance is not in Annex I or Annex II of Regulation (EC) Regulation (EC) No 1005/2009 on substances that deplete the ozone layer.

The test substance does not belong to the greenhouse gases listed in P Forster, PV Ramaswamy et al. Changes in Atmospheric Constituents and in Radiative Forcing. In: Climate Change 2007: The Physical Basis. Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change.