Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-977-3 | CAS number: 7783-06-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
Description of key information
There is a combined systemic- and reproduction toxicity study according to OECD 421 with H2S availiable (Dorman et al., 2000). In this study not only the systemic toxicity and the toxicity to reproduction was investigated but the animals, especially the pups were also examined for neurotoxicity.
In contrast to all the other neurotoxicity studies in literature an accepted guideline-conform test for evaluation of neurotoxicity had been used.
In this GLP study Dorman et al. (2000) examined the effects of an inhalation exposure to H2S. In this combined systemic- and reproduction toxicity study according to OECD 421 Groups of 12 male and 12 female Sprague-Dawley rats were exposed to hydrogen sulfide at 0, 10, 30, or 80 ppm 6 h/day, 7 days/week for 2 weeks before breeding. Exposures continued during a 2-week mating period and then on GD 0-19. Exposure of the dams and pups (eight rats per litter after culling) resumed from PND 5 to PND 18. Adult male rats were exposed on 70 consecutive days.
The offspring were evaluated on the basis of motor activity, passive avoidance, a functional observational battery, acoustic startle response, and neuropathology. There were no gross abnormalities observed at necropsy in the brain, spinal cord, or peripheral nerves of any pup.
Exposue to H2S did not affect pup growth, development, or performance on any of the behavioral tests.
The results of this study suggests that H2S is neither a reproductive toxicant nor a behavioral developmental neurotoxicant in the rat.
So the NOAEC for the neurotoxic effects was 80 ppm (111 mg/m3).
Key value for chemical safety assessment
Additional information
There is a combined systemic- and reproduction toxicity study according to OECD 421 with H2S availiable (Dorman et al., 2000). In this study not only the systemic toxicity and the toxicity to reproduction was investigated but the animals, especially the pups were also examined for neurotoxicity.
In contrast to all the other neurotoxicity studies in literature an accepted guideline-conform test for evaluation of neurotoxicity had been used in this study of Dorman et al. (2000).The offspring were evaluated using motor activity (postnatal day 13, 17,21 and 60 +-2), passive avoidance (postnatal day 22 +-1, 62 +- 3), functional observation battery (postnatal day 60 +-2), acoustic startle response (postnatal day 21, 62 +-3) and neuropathology (postnatal day 23 +-2, 61 +-2). Additionally specific histopathologic preparations have been used to detect effects on the brain, spinal cord and nerves of the animals.
No relevant gross abnormalities were observed at necropsy in the brain, spinal cord, or peripheral nerves of any pup. Exposue to H2S did not affect pup growth, development, or performance on any of the behavioral tests.
So the NOAEC for the neurotoxic effect was 80 ppm (111 mg/m3).
All the other studies reported in literature were not performed according to a guideline and used much shorter exposition times per day as the study of Dorman et al. (2000). Therefore their results are not comparable to the guideline study and these studies are judged as "not reliable" or as "not assignable" and the results of these studies are not used for the evaluation of the neurotoxicity of H2S.
Based on the respiratory lesions observed in the study with inhalation exposure by Dorman et al. (2000) H2S is calssified as H335: May cause respiratory irritation, according to the CLP-criteria/R37: Irritating to the respiratory system, according to DSD.
Justification for classification or non-classification
According to the available data and CLP/DSD criteria, no classification is warranted for neurotoxic effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.