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EC number: 215-686-9 | CAS number: 1344-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 September 1985 - 01 November 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was not performed under GLP. OECD 401 was followed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Disodium tetrasulphide
- EC Number:
- 234-805-5
- EC Name:
- Disodium tetrasulphide
- Cas Number:
- 12034-39-8
- Molecular formula:
- Na2S4
- Details on test material:
- Chemical name: Sodium tetra sulphide (natriumtetrasulfid)
Appearance: yellow ocher solid chrystals
Storage: room temperature
No further information. No CoA included in the study. For additional information see attached document.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann Versuchstierzucht GmbH & Co. KG., D-4799 Borchen
- Age at study initiation: M 68 - 73 days, F 69 - 87 days
- Weight at study initiation: M 194 - 226 g, F 151 - 179 g
- Fasting period before study: 16 hours before test substance administartion food was withheld.
- Housing: 1 per cage in makrolon type II cages
- Diet (e.g. ad libitum): ad libitum standard rodent diet, sniff (R)
- Water (e.g. ad libitum): ad libitum
- Acclimation period: minimal 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 55 ± 15
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: 20 September 1985 - 01 November 1985
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2.5-100 mg/L
- Amount of vehicle (if gavage): 2.15 ml/kg
MAXIMUM DOSE VOLUME APPLIED: 2.15 ml/kg - Doses:
- males: 100, 147, 215 mg/kg bw
females: 46.4, 100, 215 mg/kg bw - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 6-8 hours after dosing and daily after that, time of onset clinicals signs and during was noted. Time of death and number of animals is recorded. A check for mortality is performed in twice a days before- and after-noon. In weekend once per day.
Immediateky after dosing and on days 7 and 14 bodyweights are determined, also after death.
- Necropsy of survivors performed: yes
- Other examinations performed: none - Statistics:
- probitanalyse:
HUNTER, W.J., LINGK, W. and RECETT, P., Intercomparison Study on the Determination of Single Administration Toxicity in Rats, Comission of the European Commmities, Health and Safety Directorate, J. Assoc. Off. Anal. Chem 62, 864 - 873, 1979
BLISS, C.J., The Statistics of Bioassay, Academic Press, New York, 1962
FINNEY, D.J., Probit Analysis, 2nd Ed., Cambridge Univ. Press, Cambridge 1952
WEBER, E., GrundriB der biol. Statistik, F. Fischer-Verlag, Stuttgart, 7. Auflage, 1972
Results and discussion
- Preliminary study:
- Not applicable
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 130 mg/kg bw
- 95% CL:
- 81 - 180
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 128 mg/kg bw
- 95% CL:
- 66 - 324
- Mortality:
- Animals died bewteen 3-12 minutes after application. See table 1 for overview of morality.
- Clinical signs:
- other: The clinical signs observed in the animals that died were ataxia, strong klonic convulsions, reduction in muscular tone, absence of reflexes, labored breathing, difficulty breathing. The signs occur 1 minute after dosing and last until death. Animals that
- Gross pathology:
- No abnormalities observed.
- Other findings:
- None
Any other information on results incl. tables
Table 1 mortalities
Sex |
Dose (mg/kg) |
# deaths |
Total # animals |
Day 1 |
Day 2 |
Day 3 |
Day 4-15 |
|
|
|
|
a b |
a b |
a b |
a b |
|
100 |
1 |
5 |
1* |
|
|
|
|
147 |
3 |
5 |
3 * |
|
|
|
M |
215 |
5 |
5 |
5 * |
|
|
|
|
|
|
|
|
|
|
|
|
46.4 |
|
5 |
|
|
|
|
|
100 |
2 |
5 |
2 * |
|
|
|
F |
215 |
4 |
5 |
4 * |
|
|
|
*Deaths occured between 3 -12 minutes.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The LD50 for males is 130 mg/kg bw (95% CI 81 -180) and for females 128 mg/kg bw (95% CI 66 -324).
- Executive summary:
The acute oral toxicity of disodium tetrasulphide was investigated in an OECD 401 study using male and female rats in test groups containing 5 animals per sex per group. Doses: males: 100, 147, 215 mg/kg bw females: 46.4, 100, 215 mg/kg bw. The clinical signs observed in the animals that died were ataxia, strong klonic convulsions, reduction in muscular tone, absence of reflexes, labored breathing, difficulty breathing. The signs occur 1 minute after dosing and last until death. Animals that survived, exept for one male showing ataxia, did not show any clinical signs. Animals died bewteen 3-12 minutes after application. Autopsy revealed no abnormalities. The LD50 for males is 130 mg/kg bw (95% CI 81 -180)and for females 128 mg/kg bw (95% CI 66 -324).
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