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Diss Factsheets
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EC number: 202-576-0 | CAS number: 97-36-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well performed research study, conducted prior to OECD and GLP guideline implementation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Method for primary irritation, Department of transportation act
- Deviations:
- not specified
- GLP compliance:
- no
- Remarks:
- (conducted prior to GLP implementation)
Test material
- Reference substance name:
- 2',4'-dimethylacetoacetanilide
- EC Number:
- 202-576-0
- EC Name:
- 2',4'-dimethylacetoacetanilide
- Cas Number:
- 97-36-9
- Molecular formula:
- C12H15NO2
- IUPAC Name:
- 2',4'-dimethylacetoacetanilide
- Details on test material:
- - Name of test material (as cited in study report): Acetoacet-m-Xylidide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved intact and shaved abraded
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml for liquids, 0.5 g for solids
- Duration of treatment / exposure:
- 4 hrs exposure
- Observation period:
- 4, 24, 48 hrs after initial application, after first reading test sites were washed
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: animal # 2, 3, 5, 6 each
- Time point:
- other: mean of 4, 24, 48 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks:
- no effects at any time
- Remarks on result:
- other: shaved abraded
- Irritation parameter:
- erythema score
- Basis:
- other: animal # 1, 4 each
- Time point:
- other: mean of 4, 24, 48h
- Score:
- 0.3
- Reversibility:
- fully reversible within: 24h
- Remarks on result:
- other: shaved abraded
- Irritation parameter:
- erythema score
- Basis:
- other: animal # 1, 2, 3, 4, 5, 6 each
- Time point:
- other: mean of 4, 24, 48h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks:
- no effects at any time
- Remarks on result:
- other: shaved intact
- Irritation parameter:
- edema score
- Basis:
- other: animal # 1, 2, 3, 4, 5, 6 each
- Time point:
- other: mean of 4, 24, 48h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks:
- no effects at any time
- Remarks on result:
- other: shaved itact and shaved abraded
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test substance is neither skin irritating nor skin corrosive in this test.
- Executive summary:
The test item was tested for its skin irritating or skin corrosive properties according to the method for primary irritation of the Department of transportation act. Important aspects of this method (dosing, grading criteria) are in line with the current OECD guidelines. The fact, that the test substance was possibly not wetted (no data), is acceptable, because skin abrasion and occlusive covering cause similar test conditions.
Following this protocol 500 mg of the test item was applied to the shaved intact and shaved abraded skin of 6 albino rabbits. After four hours exposure time the occlusive covering was removed and the animals were examined for signs of skin irritation or corrosion. Following this, the test sites were washed. Readings were made again at 24 and 48 h after initial application. Mean scores (mean of 4, 24, 48 h) were calculated for oedema and erythema for each rabbit.
All calculated mean scores were 0 except for two rabbits whose mean score for erythema (shaved abraded) amounts to 0.3 but was fully reversible within 24h. Based on these findings the test substance is neither skin irritating nor skin corrosive in this test.
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