Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 224-221-9 | CAS number: 4253-34-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an acute oral toxicity study conducted to the now deleted OECD 401 and to GLP (Huntingdon Life Sciences, 2001) the LD50 for methylsilanetriyl triacetate was 1600 mg/kg bw in rats.
In accordance with Column 2 of REACH Annex VIII, the acute toxicity study via the inhalation route (required in Section 8.5.2) does not need to be conducted as the substance is classified as corrosive.
In accordance with Column 2 of REACH Annex VIII, the acute toxicity study via the dermal route (required in Section 8.5.3) does not need to be conducted as the substance is classified as corrosive.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12.01.2000 to 06.02.2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, New York
- Age at study initiation: 9-12 weeks
- Weight at study initiation: Males: 254-321 g; Females: 193-238 g
- Fasting period before study: yes
- Housing: Individually housed in suspended stainless steel cages
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: at least 9 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-26
- Humidity (%): 26-72
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 17.02.2000 To: 12.05.2000 - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- melted state
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1.6 ml/kg
- Doses:
- 800, 1300, 1450, 1600, 1750 and 2000 mg/kg bw/day
- No. of animals per sex per dose:
- Five
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Viability observations were made twice daily. Observations for clinical signs of toxicity were made 1, 2 and 4 hours after dosing and daily thereafter. Animals were weighed on the day before dosing, just prior to dosing, then on days 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: each animal's feed was visually inspected and compared to that of the other animals in the same test. Macroscopic examination of all animals. - Statistics:
- An estimate of the median lethal dose, with 95% confidence limits, using the method of Litchfield and Wilcoxon was performed for the combined sexes, and individually for males and females.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 600 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 516 - <= 1 694
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 550 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 437 - <= 1 661
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 660 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 545 - <= 1 780
- Mortality:
- See Table 1
- Clinical signs:
- other: Observations noted in most groups on the day of dosing included red stains on the snout/extremeties, lacrimation, excessive salivation, decreased activity, lethargy and/or prostate, irregular gait, hunched appearance, laboured breathing, rales and red uri
- Gross pathology:
- All of the rats in 800 and 1300 mg/kg group had necropsy findings within normal limits. The stomach of the rats at 1450, 1600, 1750 and/or 2000 mg/kg had abnormal contents (clear, mucinous, granular, tan, black, green), discoloured mucosa (red, brown, black) and an increased thickness of the wall. A number of these rats also had adhesions between the stomach and other abdominal viscera. Two rats at 2000 mg/kg had fluid in the abdominal cavity.
- Other findings:
- None
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In an acute oral toxicity study conducted to the now deleted OECD 401 and to GLP (reliability score 1) the LD50 for methylsilanetriyl triacetate was 1600 mg/kg bw in rats. Observations noted in most groups on the day of dosing included red stains on the snout/extremeties, lacrimation, excessive salivation, decreased activity, lethargy and/or prostate, irregular gait, hunched appearance, laboured breathing, rales and red urine, red stains of the ano-genital area and/or red stains beneath animal's cage. The clinical sign of irregular gait appeared to be generally associated with mortality. Most 1450 and 1600 mg/kg males lost weight by Day 8, but gained weight by Day 15. Most surviving females at 1600 and 1750 mg/kg gained weight by Days 8 and 15. The stomach of the rats at 1450, 1600, 1750 and/or 2000 mg/kg had abnormal contents (clear, mucinous, granular, tan, black, green), discoloured mucosa (red, brown, black) and an increased thickness of the wall. A number of these rats also had adhesions between the stomach and other abdominal viscera. Two rats at 2000 mg/kg had fluid in the abdominal cavity.
Reference
Table 1 Summary of Mortality data
Dose Level (mg/kg) | Mortality | Time of death | ||
Males | Females | Combined | ||
800a | 0/5 | 0/5 | 0/10 | |
1300 | 0/5 | 0/5 | 0/10 | |
1450 | 1/5 | - | - | Day 14 |
1600 | 4/5 | 1/5 | 5/10 | 2 hours, Day 3, 4, 5, 9 |
1750 | - | 4/5 | - | Day 3, 4, 7 |
2000 | 5/5 | 5/5 | 10/10 | 4, 22 hours, Day 2, 3, 6, 8 |
a Results from this dose group not used in LD50 determination
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 600 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an acute oral toxicity study conducted to the now deleted OECD 401 and to GLP (Huntingdon Life Sciences, 2001) the LD50 for methylsilanetriyl triacetate was 1600 mg/kg bw in rats. Observations noted in most groups on the day of dosing included red stains on the snout/extremeties, lacrimation, excessive salivation, decreased activity, lethargy and/or prostate, irregular gait, hunched appearance, laboured breathing, rales and red urine, red stains of the anogenital area and/or red stains beneath animal's cage. The clinical sign of irregular gait appeared to be generally associated with mortality. Most 1450 and 1600 mg/kg males lost weight by Day 8, but gained weight by Day 15. Most surviving females at 1600 and 1750 mg/kg gained weight by Days 8 and 15. The stomach of the rats at 1450, 1600, 1750 and/or 2000 mg/kg had abnormal contents (clear, mucinous, granular, tan, black, green), discoloured mucosa (red, brown, black) and an increased thickness of the wall. A number of these rats also had adhesions between the stomach and other abdominal viscera. Two rats at 2000 mg/kg had fluid in the abdominal cavity. In a gastric juice simulation study (Ying et al., 2002; see Section 4.1.1.1) in which methylsilanetriyl triacetate was added to simulated gastric juice, relatively high molecular weight polymers were found after 1 and 4 hours. This finding indicates that at very high gavage doses polymerisation could occur in the stomach. Therefore the abnormal stomach contents observed in the above study could have been polymerised test substance. Clinical signs and macroscopic findings appeared to be related to the corrosive properties of the test substance on the stomach.
The calculated value is in good agreement with the reported LD50 of methylsilanetriyl triacetate of 1600 mg/kg bw (rat), confirming the above assumption.
Justification for classification or non-classification
Based on the available data methylsilanetriyl triacetate is classified for acute oral toxicity Category 4, 'H302: Harmful if swallowed' according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.