Registration Dossier
Registration Dossier
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EC number: 241-004-4 | CAS number: 16940-66-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Documentation sufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 955
- Report date:
- 1955
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Sodium tetrahydroborate
- EC Number:
- 241-004-4
- EC Name:
- Sodium tetrahydroborate
- Cas Number:
- 16940-66-2
- Molecular formula:
- BH4.Na
- IUPAC Name:
- Sodium tetrahydridoborate(1–)
- Details on test material:
- - Name of test material (as cited in study report): Sodium borohydride
- Physical state: powder
Constituent 1
Test animals
- Species:
- other: rabbits, rats, and mice
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- rabbits- 1.7-2.7 kg
rats- 0.16-0.26 kg
mice- 0.015-0.028 kg
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- propylene glycol
- Remarks:
- used for mice only
- Details on exposure:
- Due to the rapid hydrolysis in solution, absolute accuracy was less important than spped and ease of application.
- Doses:
- no data
- No. of animals per sex per dose:
- 12 per species
- Control animals:
- not specified
- Statistics:
- Using the data obtained from the test, LD50's and their confidence limits were then calculated using the simplified method described by Weil (1952).
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- other: Approximate lethal dose (ALD)
- Effect level:
- 60 mg/kg bw
- Remarks on result:
- other: rabbits
- Sex:
- not specified
- Dose descriptor:
- other: Approximate lethal dose (ALD)
- Effect level:
- 18 mg/kg bw
- Remarks on result:
- other: rats
- Sex:
- not specified
- Dose descriptor:
- other: Approximate letahl dose (ALD)
- Effect level:
- < 18 mg/kg bw
- Remarks on result:
- other: mice
Applicant's summary and conclusion
- Conclusions:
- Intraperitoneal toxicity varied between species- rabbits, rats and mice. Rats and mice were more sensitive. Approximate lethal doses for rabbits, rats and mice were 60 mg/kg, 18 mg/kg and <18 mg/kg, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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