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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 223-498-3 | CAS number: 3926-62-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Reducing systemic absorption from monochloracetic acid exposure through dermal decontamination: use of the pig ear organ culture system.
- Author:
- Bruijnzeel PLB et al
- Year:
- 1 998
- Bibliographic source:
- J. Toxicol. Cut. Ocular Toxicol. 17 (2&3), 111-126
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The rates of percutaneous penetration and dermal accumulation of radiolabeled MCA were measured using the blood-perfused pig ear model.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Chloroacetic acid
- EC Number:
- 201-178-4
- EC Name:
- Chloroacetic acid
- Cas Number:
- 79-11-8
- Molecular formula:
- C2H3ClO2
- IUPAC Name:
- 2-Chloro-ethanoic acid
- Details on test material:
- [14C]MCA was used for the permeation studies (Sigma, 444 MBq/mmol). No further details specified.
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- [14C]MCA
Results and discussion
Any other information on results incl. tables
Maximum rates of percutaneous penetration (ng/min/cm2; mean + SEM) were 891 ± 335 for a 1 -min exposure, 947 ± 191 for 3 -min exposure ; and 3221 ± 515 for a 10 - min exposure.
Applicant's summary and conclusion
- Conclusions:
- Although the initial rate of percutaneous absorption (first 30 min) was directly related to the exposure time, there was no difference in maximal rates of percutaneous penetration for 1- and 3-min exposures. It appears, that for short exposure times, the percutaneous penetration rate is determined by both the rate of penetration into the skin and the rate of diffusion from dermal stores into the blood.
A saturated sodium bicarbonate solution and water proved equally effective in decontaminating the skin after a 10-min exposure to MCA. However, a saturated bicarbonate solution was a slightly more effective decontaminant than water after a 1-min exposure. The data indicate that decontamination should take place as soon as possible after dermal contamination with MCA. Furthermore, decontamination should continue for as long as possible in order to reduce the systemic burden.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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