Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: Expert review and assessment
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Not assignable as the result is from expert assessment.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Objective of study:
other: Basic toxicokinetic assessment to support REACH registration
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Expert review of available data.
GLP compliance:
no

Test material

1
Reference substance name:
3-hydroxypropan-1-aminium; tetrahydroxyspiro[5.5]pentaboroxan-6-uide
EC Number:
701-025-6
Cas Number:
26038-87-9
Molecular formula:
C2H7NO.BH3O3
IUPAC Name:
3-hydroxypropan-1-aminium; tetrahydroxyspiro[5.5]pentaboroxan-6-uide
Test material form:
liquid
Details on test material:
Appearance: Clear colourless liquid
Purity/Composition: UVCB
Test item storage: At room temperature protected from light
Stable under storage conditions until: 31 March 2018 (expiry date)

Results and discussion

Any other information on results incl. tables

No toxicokinetic (absorption, metabolism, distribution, elimination) data is available for MEA-Polyborate. Available data is primarily physico-chemical properties that influence the absorption and distribution of the substance in the body. Both 1:1 and 1:3 mole ratios of MEA to boric acid are infinitely soluble in water with log Pow of -0.9 for the polyborate moiety by ICP-MS and log Pow of -2.5 for the organic moiety by LC-MS. The log P values indicate that both ratios of MEA-Polyborate will likely be 100% absorbed in the gastrointestinal track, primarily found in the blood serum and excreted primarily via the kidneys in the urine. The log P values also indicate that both ratios of MEA-Polyborate is poorly absorbed through the skin with dermal absorption rates similar to monoethanolamine. No data is available on the metabolism of MEA-Polyborate.

Applicant's summary and conclusion

Conclusions:
No toxicokinetic (absorption, metabolism, distribution, elimination) data is available for MEA-Polyborate. Available data is primarily physico-chemical properties that influence the absorption and distribution of the substance in the body. Both 1:1 and 1:3 mole ratios of MEA to boric acid are infinitely soluble in water with log Pow of -0.9 for the polyborate moiety by ICP-MS and log Pow of -2.5 for the organic moiety by LC-MS. The log P values indicate that both ratios of MEA-Polyborate will likely be 100% absorbed in the gastrointestinal track, primarily found in the blood serum and excreted primarily via the kidneys in the urine. The log P values also indicate that both ratios of MEA-Polyborate is poorly absorbed through the skin with dermal absorption rates similar to monoethanolamine. No data is available on the metabolism of MEA-Polyborate.