Adipic acid, compound with hexane-1,6-diamine (1:1)

Endpoint summary

Additional information

In aqueous solution, AH-salt rapidly dissociates to Adipic acid (CAS: 124 -04 -9) and 1.6 Hexamethylenediamine (CAS: 124 -09 -4). Both dissociation products are acute harmful to aquatic organisms with effect concentrations ranging from approximately 10 to 100 mg/l, respectively. For AH-salt, acute toxicity studies are available for fish, daphnia and algae and by thereby comprising three trophic levels. The less sensitive organism group is fish with an LC50 (96h) > 470 mg/l as reported for Rainbow trout and Bluegill (ABC Laboratories 1981). For the green alga Scenedesmus subspicatus a EµC50 (72h) of 537.8 mg/l and a NOEC (72h) of 125 mg/l were determined (BASF AG 1987; ECT 2010). The most sensitive organism is Daphnia magna, exhibiting an EC50 (48h) of 90 mg/l (ABC Laboratories 1981). Therefore AH-salt can be considered as acutely harmful to aquatic organisms underlining the observations on dissociation products. There are no chronic studies for fish and aquatic invertebrates available for AH-salt, however, in two reproduction tests, performed according to OECD guideline 211, no effect concentrations (NOEC) of 6.3 and 4.2 mg/l for Adipic acid (CAS: 124 -04 -9) and 1.6 Hexamethylenediamine (CAS: 124 -09 -4) were observed, clearly underlining the little hazard potential of AH-salt (MOE 1997, 2002). The lower NOEC of 4.2 mg/l for Hexamethylendiamine was used for the derivation of PNEC_aqua.