Dichromium tris(chromate)

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

sub-chronic toxicity: inhalation

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well reported literature study, but non-standard design. Findings are consistent with those in other similar studies.

Data source

Reference

Reference Type:

publication

Title:

Effects of chromium compounds on the respiratory system. Part 4. Long-term inhalation of chromic acid mist in electroplating to ICR female mice

Author:

Adachi S, Yoshimura H, Katayama H, Takemoto K

Year:

1986

Bibliographic source:

Japanese Journal of Industrial Health 28(4): 283-287

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Respiratory tract toxicity was investigated following repeated inhalation exposure to chromic acid mist for two 30 minute periods a week for 6-12 months.

GLP compliance:

no

Remarks:

published literature study

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Chromium trioxide

EC Number:

215-607-8

EC Name:

Chromium trioxide

Cas Number:

1333-82-0

Molecular formula:

CrO3

IUPAC Name:

chromium trioxide

Details on test material:

Mice were exposed to aqueous solutions of chromium trioxide (chromic acid (mist)). No further details are given.

Test animals

Species:

mouse

Strain:

ICR

Sex:

female

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

other: water; chromic acid is aqueous chromium trioxide

Remarks on MMAD:

MMAD / GSD: 85% of the mist particles are reported to have been <5 µm diameter and 97% were <10 µm diameter.

Analytical verification of doses or concentrations:

yes

Duration of treatment / exposure:

Mice were exposed for two periods of 30 minutes per week, for 6-12 months.

Frequency of treatment:

Mice were exposed for two periods of 30 minutes per week, for 6-12 months.

No. of animals per sex per dose:

Exposed animals were terminated at 6-9 months (15 mice), 10-14 months (14 mice) and all remaining animals at 15-18 months (19 mice). Control
animals (10) were terminated at 12 and 18 months.

Control animals:

yes, concurrent no treatment

Results and discussion

Effect levels

Dose descriptor:

LOAEC

Effect level:

3.63 mg/m³ air

Sex:

female

Basis for effect level:

other: Irritant and corrosive effects were observed at 3.63 mg/m³ - the only exposure concentration evaluated

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

Irritant and corrosive effects in the respiratory tract (perforated nasal septum, tracheal and bronchial epithelial hyperplasia, emphysema) occurred in treated animals.

Applicant's summary and conclusion

Conclusions:

Exposure to chromic acid mist at the exposure level equivalent to 3.63 mg Cr/m³ for 6-12 months was found to induce changes consistent with irritation and corrosion in the respiratory tract of female mice.

Executive summary:

Female ICR mice were exposed to chromic acid mist at a concentration equivalent to 3.63 mg Cr/m³ for two 30 -minute periods a week for 6 -12 months. The study focused on local effects only. Exposure was found to induce changes consisitent with irritation and corrosion in the respiratory tract.