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EC number: 201-058-1 | CAS number: 77-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: case report
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Occupational allergic contact dermatitis due to dimethyl sulfate following sensitization from a severe acute irritant reaction to the reagent
- Author:
- Yagami, A.
- Year:
- 2 009
- Bibliographic source:
- Contact Derm. 60, 183-184
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- After an accident with DMS and the assumption that allergic contact dermatitis to DMS occured a patch test using DMS dilution series (0.1% pet to 0.0001% pet) in white pet was performed.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl sulphate
- EC Number:
- 201-058-1
- EC Name:
- Dimethyl sulphate
- Cas Number:
- 77-78-1
- Molecular formula:
- C2H6O4S
- IUPAC Name:
- dimethyl sulfate
- Details on test material:
- - Name of test material (as cited in study report): Dimethyl sulphate
- Physical state: liquid
- no further significant data stated
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 1
- Sex: male
- Age: no data
- Race: human, japanese - Clinical history:
- for details see "details on study design"
- Controls:
- no controls
- Route of administration:
- dermal
- Details on study design:
- Human case study with additional patch testing:
A 26 -year old Japanese man spilled 100% DMS on his clothing at work. He changed out of the affected clothing 30 min after the accident but did not change his underwear. Our later, blister, redness and swelling were noticed in his genital area. In addition skin eruptions were evident on his right elbow. His symptoms improved with treatment, but new itchy eruptions appeared on his face and extremities on day 8 and disappeared on day 18. On work day 1, he was exposed to DMS again (shoes were not cleaned). Several hours later, itchy erythema recurred at the sites previously affected by the acute irritant reaction. A skin biopsy from the left thigh showed epidermal hyperplasia, sponginess, and a dense perivascular cell infiltrate from the shallow to deep layers of the dermis to assess if occurred a patch test was performed (1 to 0.0001%, each with the patient and two controls). One week later, there was a positive skin reaction to 1% pet and no reaction to 0.01% pet observed at the skin of the patient. In the controls at 1% pet a skin reaction was observed but not at the skin of the control exposed to the 0.1% pet.
Results and discussion
- Results of examinations:
- One week after exposure, there was a positive skin reaction to 1% pet and no reaction to 0.01% pet observed at the skin of the patient. In the controls at 1% pet a skin reaction was observed but not at the skin of the control exposed to the 0.1% pet.
Applicant's summary and conclusion
- Conclusions:
- On basis of the results, it can be stated that the patient has an allergic contact dermatitis to DMS and concluded that a suitable concentration of DMS for patch testing was 0.1% pet.
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