Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Glp guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
other: Directive 83/467/EEC
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
65996-93-2
Cas Number:
65996-93-2
IUPAC Name:
65996-93-2
Constituent 2
Reference substance name:
Pitch, coal tar, high-temp.
EC Number:
266-028-2
EC Name:
Pitch, coal tar, high-temp.
IUPAC Name:
266-028-2
Constituent 3
Reference substance name:
Pitch, coal tar, high-temp.
IUPAC Name:
Pitch, coal tar, high-temp.
Details on test material:
Electrode binder [CAS No. 65996-93-2]
- Name of test material (as cited in study report): 101.110
- Substance type: organic
- Physical state: solid, black powder

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Harald Schriever, Kaninchenfarm, Bremerförde/Germany
- Age at study initiation: no data
- Weight at study initiation: 2.4 - 2.8 kg
- Housing: cage, single
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: >= 7 d


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 +-2 °C
- Humidity (%): 50 - 86 %
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 / 12


Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
other: none
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g

Duration of treatment / exposure:
4 hour(s)
Observation period:
readings: 1 h, 24, 48, and 72 h after removal of the cover
Number of animals:
6
Details on study design:
TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- skin intact and scarified

REMOVAL OF TEST SUBSTANCE
- Washing (if done): luke-warm water
- Time after start of exposure: 4 h


SCORING SYSTEM: according to Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: 1 to 6
Time point:
other: 1, 24, 48, and 72 h
Score:
0
Max. score:
4
Remarks on result:
other: score 0 in all animals at any time point both on the intact and scarified skin
Irritation parameter:
edema score
Basis:
animal: 1 to 6
Time point:
other: 1, 24, 48, and 72 h
Score:
0
Max. score:
4
Remarks on result:
other: score 0 in all animals at any time point both on the intact and scarified skin
Irritant / corrosive response data:
There was no skin reaction over the observation time of 72 h (score 0).

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU