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EC number: 276-957-5 | CAS number: 72869-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- yes
- Remarks:
- Husbandry: Relative humidity in the animal room was 45-92% for about 10 hours.
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 7,7,9(or 7,9,9)-trimethyl-4,13-dioxo-3,14-dioxa-5,12-diazahexadecane-1,16-diyl bismethacrylate
- EC Number:
- 276-957-5
- EC Name:
- 7,7,9(or 7,9,9)-trimethyl-4,13-dioxo-3,14-dioxa-5,12-diazahexadecane-1,16-diyl bismethacrylate
- Cas Number:
- 72869-86-4
- Molecular formula:
- C23H38N2O8
- IUPAC Name:
- 7,7,9(or 7,9,9)-trimethyl-4,13-dioxo-3,14-dioxa-5,12-diazahexadecane-1,16-diyl bismethacrylate
- Details on test material:
- Batch No. 81106228
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- dimethylformamide
- Concentration:
- 10, 25. 50 % PC-Cure P-1001 in dimethylformamide
- No. of animals per dose:
- 4
- Details on study design:
- Vehicle and Dose Selection
A solubility experiment was performed according to the recommendations given by OECD
429. The highest test item concentration, which can be technically used was a 50 % (w/w)
solution in dimethylformamide. Vortexing and warming to 37°C for about 10 minutes were
necessary to dissolve the test item.
To determine the highest non-irritant test concentration, a pre-test was performed in two
animals. Two mice were treated with concentrations of 25 and 50% each on three
consecutive days.
In the pre-test clinical signs were recorded within 1 hour and 24 ± 4 hours after each
application as well as on day 8. At the tested concentrations the animals did not show any
signs of irritation or systemic toxicity.
The test item in the main study was assayed at 10, 25 and 50%. The top dose is the
highest technically achievable concentration whilst avoiding systemic toxicity and
excessive local irritation. No severe irritant effects were tolerated choosing the test
concentrations.
Each test group was treated by topical application to the dorsal surface of each ear lobe with different test item concentrations. The application volume 25 microL was spread over the dorsal surface once daily for three consecutive days. Five days after the first application, all mice were administered with 250 microL of 3HTdR by intravenous injection. Five hours after treatment with 3HtdR all mice were euthanised and the draining lymph nodes were rapidly excised and pooled per group. - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
- Positive control results:
- EC3 = 7.8 % (w/v)
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: 0%: 1.00 10%: 1.58 25 %: 1.70 50%: 4.44
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: group 1 (0%): 6433 DPM group 2 (10%): 10151 DPM group 3 (25%): 10929 DPM group 4 (50 %): 28518 DPM
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- The test item PC-Cure P-1001 was found to be a skin sensitiser. The EC 3 value was calculated as 36.9%.
- Executive summary:
The test item PC-Cure P-1001 was found to be a skin sensitiser. The EC 3 value was calculated as 36.9%.
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