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EC number: 221-220-5 | CAS number: 3033-62-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion:
The test substance is considered to be corrosive to skin based on skin irritation studies conducted in rabbits that reported severe irritation (erythema) and corrosion following a 60-minute exposure to the test substance.
Eye irritation:
The test substance is considered to be corrosive to the eyes based
on an eye irritation study conducted in rabbits indicating that the test
substance is extremely irritating and the effects were not reversible
within 72 hours.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion
The key skin irritation study had a reliability score of 1 and was GLP compliant (WIL, 1996). The test protocol was OECD 404 and DOT 49 CFR 173.137. One New Zealand White rabbit was dosed to evaluate the irritative/corrosive potential of the test material for three and 60 minutes. The study consisted of two sequential single 0.5 mL doses of the test material that were applied to the clipped, intact skin of one rabbit under semi-occlusive dressings. Moderate erythema was observed on the 3-minute site immediately following unwrap. Approximately one hour following bandage removal, the 3-minute site had severe erythema, very slight edema and fissuring. There was no evidence of corrosion following the 3-minute exposure. The 60-minute site had corrosion, severe erythema and blanching. Since severe irritation (erythema) and corrosion were observed after the 60-minutes exposure period no further testing was conducted and the study was terminated. Based on the results, a four-hour exposure was not evaluated.
In addition, three reliable supporting studies are available, all of which found the test substance to be corrosive to the skin of rabbits.
No in vitro studies were performed with the test substance.
Eye irritation
The key eye irritation study had a reliability score of 2 and was performed in New Zealand White rabbits using a method equivalent or similar to the OECD 405 guideline and in compliance with the GLP Regulations. Following a one second exposure to the test substance, ocular responses were assessed using the Draize scoring system. Maximum mean total scores (MMTS) at 1 hour, 24 and 48 hours, and 72 hours post-exposure were 75.7, 102.3 and 105.4, respectively. Necrosis of the skin surrounding the treated eyes was also observed during the course of the study. Due to the severity of the reactions prior to the Day 7 reading, the study was terminated. The test substance was reported to be extremely irritating on the basis of the 72-hr Draize Score of 105.4.
No in vitro studies are available for this endpoint.
Justification for classification or non-classification
Based on the available results, the suggested classification for the test substance according to the EU CLP Regulation 1272/2008 is skin corrosion Category 1B and eye damage Category 1 - Causes severe skin burns and eye damage, H314.
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