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Diss Factsheets
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EC number: 202-636-6 | CAS number: 98-09-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study similar to OECD 403 guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Benzenesulphonyl chloride
- EC Number:
- 202-636-6
- EC Name:
- Benzenesulphonyl chloride
- Cas Number:
- 98-09-9
- Molecular formula:
- C6H5ClO2S
- IUPAC Name:
- benzenesulfonyl chloride
- Details on test material:
- - Name of test material (as cited in study report): Benzenesulfonyl Chloride
- Molecular formula (if other than submission substance): C6H5ClO2S
- Molecular weight (if other than submission substance): 176.62
- Physical state: Brown liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: purchased from Charles River Laboratories (Kingston, NY)
- Age at study initiation: 9 weeks
- Weight at study initiation: males ca. 285 g and females ca. 189 g
- Fasting period before study: no
- Housing: housed singly in 7" wide x 9.5" deep x 7" high stainless steel wire bottom cages (Lab Products, Inc., Rochelle Park, NJ)
- Diet (e.g. ad libitum): Purina Certified Laboratory Rodent Chow #5002, Ralston Purina, St. louis, MO : ad libitum
- Water (e.g. ad libitum): Tap water ad libitum
- Acclimation period: 12 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 °C
- Humidity (%): 40% - 60%
- Air changes (per hr): 12.6
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: inhalation chamber obtained from a commercial supplier (Young and Bertke Co., Cincinnati, OH) and is similar to the EPA design described by Hinners and coworkers. The chamber is constructed of stainless steel and glass.
- Exposure chamber volume: 447 liters
- Method of holding animals in test chamber: individualy caged in a compartmented stainless steel wire cage (5" x 8" x 7")
- Source and rate of air: conditioned room aire passed through an absolute filter
- System of generating particulates/aerosols: Solosphere nebulizer (Miller, et al., 1981)
- Method of particle size determination: by a low volume cascade impactor (Aries, Inc., Davis, CA)
- Treatment of exhaust air: passed through an absolute filter to remove particulate contaminants, and through an activated charcoal element to remove vapor contaminants, then further purified by the building exhaust system before release.
TEST ATMOSPHERE
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): MMAD of 4.40µm with GSD of 1.18 - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 1 h
- Concentrations:
- The mean total chamber air concentration of BSC was 1.87 mg/l with a standard deviation of +- 0.10. The calculated nominal concentration was 6.85 mg/l.
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Rats were observed frequently during exposure. After exposure, the rats will be observed twice a day and all clinical signs and mortalities will be recorded.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight: body weights will be recorded on day 0, 7 and 14. - Statistics:
- Body weights wil be compared to their day 0 weights to check for significant weight gain or depression using Student's paired T-test
Results and discussion
- Mortality:
- A one-hour inhalation exposure of rats to 1.87 mg/l BSC caused 9 death (90%)
- Clinical signs:
- other: Reduced activity, wet muzzles, dyspnea/wheezing, dacryorrhea, chromodacryorrhea, chromorhinorrhea, brown flacks on chin and face, wet pelvic/ventral areas and some hair loss.
- Other findings:
- Necropsy findings suggest death was due to pulmonary insufficiency evidenced by pulmonary congestion.
Any other information on results incl. tables
No endpoint has been calculated ; A one-hour inhalation exposure of rats to 1.87 mg/l BSC caused 9 death (90%)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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